Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Well, that’s it, kids: we’re heading home. Chinese shares are down 7 per cent, and thanks to the newly-instituted market circuit breakers, that means the market shuts.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Banks, asset managers and insurance companies have flocked from mainland China to acquire prime Hong Kong office buildings, prompting the territory’s government to announce it will release more land for commercial redevelopment in the oversubscribed heart of the city.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Comic skit “Happiness Of Today II” (Shen Teng, Ma Li etc)
The worst of 2015
Trends and targets in antiviral phototherapy
Chinese Premier Li Keqiang said the economy performed better than forecast in 2017 and expects annual gross domestic product growth of around 6.9 per cent, according to state media.
Those with 3-years of driving experience and no records of traffic accident crimes, dangerous driving, drugs or drink driving will be allowed to take examinations for online-driving services.
“An interviewer walked inta closet instead of the meeting room.”
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Not because I am happy to see the end of what was one of television’s smartest series, a pioneer of what is now generally accepted as the current golden age of small-screen serials.
ACE2 as a potential therapeutic target for pandemic COVID-19
The cemetery was first found in July 2007and was excavated by the Xinjiang Institute of Cultural Relics and Archaeology,with assistance from local authorities. The research team, led by Zhiyong Yu,director of the Xinjiang Archaeological Institute, published the findings in Chinese in the journal Wenwu. The article was recently translated into Englishand published in the journal Chinese Cultural Relics.
Diagnostic technologies for COVID-19: a review
Weaker demand from emerging markets made 2015 the worst year for world trade since the aftermath of the global financial crisis, highlighting rising fears about the health of the global economy.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
The report by iResearch Consulting Group and Sina Weibo, China's most popular microblogging platform, was released at a forum in Shanghai, co-organized by Weibo and telecom giant Huawei .
The CHIP, which retails for $150, can only bake four full-sized cookies at a time. If you were go the traditional way and bake a large batch in the oven, you'd have anywhere between eight and 12 cookies in under 30 minutes — and it's also cheaper.
We will endeavor to transform and upgrade traditional industries.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Life Is Strange
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Here is my best guess - and that's all it is - for how the U.S. economy and markets will look in 2010:
Influenza neuraminidase: A druggable target for natural products
《大城小妞》(Broad City)，Comedy Central，1月14日播出。伊拉纳·格雷泽(Ilana Glazer)与艾比·雅克布逊(Abbi Jacobson)带着第二季回归了，它讽刺了纽约那些大材小用而又自恋的人们生活中的故作姿态、妥协与纯粹粗俗。
Matt Damon was named best actor in a comedy or musical motion picture for his role as a stranded astronaut in The Martian.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Third, McDermott provides some protection against the possibility of Andre Roberson departing as a free agent in the summer.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Dachis says: The news just keeps getting worse for Mitsubishi. Low sales triggered a decision to pull out of the European market and if the levels of negative discussion are any indicator, 2013 doesn’t look to be any better.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
But national and racial identity were often conflated for the white majority. That identity felt to many white people like one of the most important pillars holding up their world — and now it seems under threat.
Over 90 percent of them attended schools in English-speaking countries, such as the US, the UK and Australia, and over 70 percent pursue at least a bachelor's degree, according to the MOE.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Jennifer Lawrence also took home the gong for best actress in a movie for her role in the critical darling Joy.
The predictions of no further action in an annual Financial Times poll of eurozone analysts came despite Mr Draghi’s attempts to convince markets that the ECB remained primed to act should inflation and growth across the single currency area continue to disappoint.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
1. Jennifer Lawrence
Inhibition of SARS coronavirus helicase by bismuth complexes
9. The 2012 Ig Nobel Anatomy Prize
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Despite the reported success of the Duke and Duchess of Cambridge's official visit to Canada back in September, timekeeping needs to be looked at for future trips.
Global smartphone shipments reached 1.47 billion units in 2016, up by 2.3 percent from last year, said IDC.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
“What Happened, Miss Simone?” (Liz Garbus)
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
The biggest story of the festival had nothing to do with films. It was about shoes. On Tuesday trade magazine Screen reported that a group of women had been denied access to a screening of Todd Haynes' Carol because their footwear – flat shoes with rhinestones – was unsuitable for the red carpet. Further tales came tumbling forth, social media erupted in indignation and soon enough we were soon dealing with a fully fledgedscandale. The Cannes press office rushed out a garbled statement: “Rules have not changed throughout the years (Tuxedo, formal dress for Gala screenings) and there is no specific mention about the height of the women's heels as well as for men's. Thus, in order to make sure that this rule is respected, the festival's hosts and hostesses were reminded of it.” Well, that cleared that up. Perhaps wisely, press screenings are exempt from any dress code: scruffy journalists are free to ascend the Palais' steps in flip flops and trainers.
16. Most Ignored Truism “There’s a myth in the business that young males drive the box office,” Tom Rothman, the chairman of Sony Pictures Entertainment’s motion picture group, told The Hollywood Reporter in November. In this same interview, Alan F. Horn, the chairman of the Walt Disney Studios, tried to make it simple: “There are variables that do affect what one pays any performer. Angelina Jolie, for example, got a lot more money for ‘Maleficent’ than Daisy Ridley did for ‘Star Wars,’ but they’re both women.” (Gee, thanks, Alan!)
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
In August, the holdings were to the tune of $80.4 billion while it stood at $79.7 billion in July.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
vt. 作 ... 姿
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
She had recently emerged as the right hand of her father, the former Prime Minister Nawaz Sharif. But corruption charges are clouding her rapid rise.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
After 'Gravity' and 'American Hustle,' my picks are in alphabetical order:
Song “The Spring Blossom” (Na Ying)
Every point we think we've reached where James cannot be better than he has been, he then blows past it like a poor center switched onto him. What will be discussed most is his all-encompassing skill, but this is also a testament to the work that James puts in. You can mock all those Instagram videos he puts up, but those are the real reason he's still able to do this; James has never cheated the game, not a day in his life, and the result is incomparable performance night in and night out.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
What dangers does the Fed present to EMs today? One of the biggest risks, says Mr Koepke, is that it might “get behind the curve” and delay raising rates for too long. This would result not only in a surprisingly big hike when it came, but also a higher terminal interest rate than would otherwise be the case.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Every four years, Allianz holds an international Olympics for its sports teams. The company covers the athletes' expenses and has an opening ceremony; in 2010, the games were held in Budapest with over 70 countries participating.
He also has serious thrill issues dude.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
《患难与共》(Togetherness)，HBO，1月11日播出。HBO台的周日晚间喜剧组合中已经有了20出头的纽约女人（《都市女孩》[Girls]第四季第一集将在同一天晚上播出），还有快到30岁的旧金山男同性恋（《寻》[Looking]也在当天开播第二季）。现在又来了30多岁的洛杉矶异性恋者们。这部有点阴郁的半小时喜剧来自杰伊(Jay)和马克·杜普拉斯(Mark Duplass)，兄弟俩曾经合拍过《肥大的椅子》(The Puffy Chair)和《纸袋头》(Baghead)等诡异的电影。马克·杜普拉斯和梅兰妮·林斯基(Melanie Lynskey)饰演一对夫妻，和杜普拉斯最好的朋友（史蒂夫·齐西斯[Steve Zissis]饰演）与林斯基的姊妹（阿曼达·皮特[Amanda Peet]饰）合住一栋房子。
The January-to-November period in the United States this year was the warmest first 11 months of any year on record for the contiguous states. And 2012 will likely surpass 1998 as the warmest year on record for the nation, according to the National Oceanic and Atmospheric Administration.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Unfortunately for May, the big drop in the pound since the Brexit vote means her salary has plunged in dollar terms.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
US listings were up from 2016, which marked the one of the weakest periods in years. According to Dealogic, 112 IPOs have priced year to date, versus just 63 at this time last year. Issuance volume has more than doubled to $31.6bn.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
The drama got 7.2 points on Douban, receiving criticism for having too much romance and too few of Zhou's struggles.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
节目29 创意乐舞《指尖与足尖》，郎朗 侯宏澜
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
2.You Never Have a Day When You Wake Up Excited To Go To Work
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
9. How to reset iPod
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Sam Smith is a fluid soul man, with style channeling Otis Redding, Aretha Franklin and Ray Charles alongside modern icons like Amy Winehouse and Adele.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Analysts survey by Bloomberg expected a rise to 1.9 per cent in January.
The unemployment rate probably won't fall quite as rapidly in 2015, according to economists, especially if more people enter the labor force because jobs are easier to find. Yet another large spate of hiring similar to the gain in 2014 would make the low unemployment rate more believable.
We'll start our review with the South American nations, and who else could we begin with, but the hosts Brazil. Rewind 18 months and they looked like they'd be struggling, but the appointment of 'Big Phil' Scolari has been inspired, and he's brought a belief to the team that was previously missing. Last years 3:0 demolition of Spain in the Confederations Cup final shocked many experts, and all of a sudden the Brazilians have expectations on them. Whilst you can't argue with that scoreline, we still wonder if Brazil have the firepower to win such a long tournament. Neymar is expected to conjure up the magic, but they're relying on Fred to come up with the goals. No disrepect to Fred, but the last two Brazilian teams to win the World Cup, in 2002 and 1994, could count on the likes of Ronaldo and Romario to lead the front line, two genuine legends of the game.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
The University of St Gallen’s domination of the Financial Times’ ranking of masters in management courses continues for another year.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
"He was not on the intelligence services' radar," added the prime minister.
It pours the perfect pint from the bottom of the glass.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The thing about the Mavericks is that this is not at all how Dirk should go out. That team has been so solid his entire career. To have a busted season now is painful. Maybe he ought to have joined Kobe, KG, and Big Fundamental last summer.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
For now, occasional high-ticket deals such as the Dah Sing Financial Centre and the purchase of a HK$2.1bn luxury house on the affluent Peak, come amid wider pessimism about the sector. The office sector showed the most activity in the first quarter this year, but this still translated into only eight deals in total, according to CBRE.
Premiered in August, the 48-episode TV series is a fictional story, with a plot centering on struggles and romance during the Qin Dynasty (221-206 BC).
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
The book reflects growing anxiety in some quarters about the possible negative impact of automation on jobs, from manufacturing to professional services. The subtitle of its UK edition warns of “the threat of mass unemployment” and, in the US edition, foresees “a jobless future”.
So take a look. I sincerely hope you enjoy reading them as much as I liked selecting and editing them.
Length-scale dependence of protein hydration-shell density
“What Happened, Miss Simone?” (Liz Garbus)
Canada, the second largest country in the world in terms of landmass, ranks No. 2 overall. It takes top spots in Quality of Life and Best Countries for Education.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Here are the 10 winners of the 2012 Ig Nobel Prizes given to scientists, writers, and peacemakers who make silly but thoughtful contributions to the world, or as the Annals of Improbable Research puts it, "first make people laugh, and then make them think." I can vouch for them making us laugh!
Hidrate Spark 2会通过移动App跟踪你的水摄入量和记录你一天喝了多少盎司的水，还可以根据在有盎司数标识的水瓶里灌了几次水来跟踪你的饮水量。
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The U.S. Congress and the media will go berserk when Goldman announces the size of its 2009 bonus pool. But the outrage will be brief and of little lasting consequence. The 'hate Goldman Sachs' story has been running just too long.
About this collection
The story of the strong V-shaped recovery of the Chinese economy this year was followed by reports of soaring housing prices in many cities.