Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
They will get more creative in 2018, including on non-cash benefits. Bank of America, for example, has just introduced a programme allowing employees of the global banking and markets unit to take a sabbatical — on full pay — for up to six weeks in a year. There are conditions: people must have been with the bank for at least a decade, and can request the time once every five years, to a maximum of three. But in a memo circulated this week, seen by the Financial Times, chief operating officer Tom Montag urged eligible employees to consider it.
It pours the perfect pint from the bottom of the glass.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Most of the cellphones sold in 2016 are smart phones installed with the Android system and 4G ready, according to the report.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Apple Inc.'s Chief Executive Officer Steve Jobs is shown in this combination photo of file photographs dating (top row L to R) July 2000, November 2003, September 2005, (bottom L to R) September 2006, January 2007 and September 2008. Jobs will take a medical leave of absence until the end of June because his health problems are "more complex" than he had thought, shocking investors and sending the company's shares down as much as 10 percent on January 14, 2009.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
这个发型与米歇尔·法伊弗(Michelle Pfeiffer)的造型有点相似，但查斯坦让它更具锋芒。凯·乔治乌(Kay Georgiou)负责这个造型。她经常为马特·达蒙(Matt Damon)和格温妮丝·帕特洛(Gwyneth Paltrow)在电影中设计发型。
1号 what the fuck: “职场辣妈”的新境界
Rogers, unhappy with the turn of events, decided to leave the show after the first three seasons. The breach of contract led to a multi-million dollar lawsuit. Ironically, Wayne Rogers had never signed his contract to begin with (he had a problem with a morals clause). The lawsuit was thrown out. You could say Rogers got the last laugh, but since M·A·S·H went on for eight more seasons and Rogers' never reached the same career success again, the last laugh might be a relative concept.
In a bid to raise awareness of one of the world's most endangered species and the Chengdu Panda Base in China, the 108 performers were hard to miss as they entertained Londoners and children during school visits with conservationist and base ambassador Nigel Marven.
Trends and targets in antiviral phototherapy
Bangkok's 2014-15 fall from the top was largely put down to political instability in recent years.
Ferreira added that while the entire Brazilian population has suffered during preparations for the World Cup, mostly because of big construction projects that have snarled traffic and extended already long commutes for the poor who live on the outskirts of cities, she feels like only the rich are reaping the benefits of the real World Cup experience.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Puerto Ricans have been hit with dozens of new taxes in the past four years and increases in utility bills as former Gov. Alejandro Garcia Padilla aimed to generate more revenue for a government he said was running out of money. Despite those and other measures, the island’s government has defaulted on millions of dollars’ worth of bond payments and declared a state of emergency at several agencies.
ACE2 as a potential therapeutic target for pandemic COVID-19
Bernard Baumohl, chief global economist of the Economic Outlook Group, said he is even more optimistic. "The next two years could be the best two we have seen in at least a decade," he said. "There is clearly a lot of evidence the economy is gaining a lot of momentum."
Diagnostic technologies for COVID-19: a review
《弗鲁特维尔车站》(Fruitvale Station)是另一部出色的故事片处女作，由瑞安?库格勒(Ryan Coogler)执导。这部影片的主题是赤手空拳的22岁黑人奥斯卡?格兰特(Oscar Grant)在加州奥克兰与一名白人交警发生冲突而遭到误杀，这本来可以成就一部纪录片。库格勒有更好的想法，将这个真实事件加以戏剧化改编，并在很大程度上进行了虚构，讲述了奥斯卡死亡前一天的生活。饰演这个角色的是迈克尔?乔丹(Michael Jordan)，他的表演能让你心碎，也能令人欢乐不已，有时是两者兼具。
节目4 小品《我要上春晚》，周炜 刘大成 石头 张尧等
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Who greets a member of any royal family, however young, with a high five?
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
We will strive to boost employment and business startups.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Two arrests have been made in connection to the shooting death of 14-year-old Lecent Ross, police said Thursday.
Mr. Lyons took a casting of Ms. Swinton’s mouth and designed teeth to fit. Those were clipped on over Ms. Swinton’s real teeth. For Minister Mason, he came up with a quirky look but didn’t quite want it to be comical. He was, however, interested in adding a little bling. “There’s a little bit of gold on the left-hand side,” he said. “We used real gold to make the filling of one tooth. We did it to put more character into the character.”
n. 沼地，极多，回转 n. 大量，许多 v. 使转，扭
Influenza neuraminidase: A druggable target for natural products
Growth in the key sectors driving China’s economy softened last month, according to official gauges tracking activity at manufacturing, services and construction businesses.
So the messaging apps have gotten creative. Tango, for example, inserts ads within a user’s messaging “inbox.” WeChat, a popular Chinese app that is owned by Tencent, makes money through games, stickers (which are similar to emojis), and mobile commerce. Kik offers a feature that some are calling “chatvertising,” where users hold conversations with chat-bots powered by brands like Funny or Die and Moviefone.
If you are a working-class white person and you fear that the new, cosmopolitan world will destroy or diminish an identity you cherish, you have no culturally acceptable way to articulate what you perceive as a crisis.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
7. Hearing Aid
This quote is the only one picked for the list that didn’t come originally from the Web, but rather from the real world. A government official evading a journalist’s persistent question about the annual total of car loans repaid in Tianjin simply said, “We can’t go into detail on this matter,” which apparently Netizens found really laughable.
The role of biosensors in the detection of emerging infectious diseases
Insead is distinguished not only by its one-year programme but also a strongly international culture, based upon its two campuses, and one of the most extensive and diverse alumni networks. The programme is ranked third for the international mobility of its alumni and sixth for international course experience.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Lopez Short is the name of the game, judging from the red carpet looks of Beyoncé and Jennifer Lopez. Both divas went for thigh-high dresses to show off their gams4, with strategically cut out neck and shoulder detail, but where Beyoncé opted to stand out in fire engine red, J. Lo went for soft and satiny earth tones.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
A host of examples of the demagogic route to power exists, in both past and present.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The Canadian city of Vancouver remains the most expensive location in North America, ranked 21st in the index.
宾夕法尼亚州立大学的气候科学家迈克尔·E·曼恩(Michael E. Mann)在电子邮件中说，“如果不是由于燃烧化石燃料所产生的、导致地球变暖的气体排放越来越多的原因，在上千年史无前例的几十年较暖期间、创纪录地变暖的十年中，看到变暖的又一个记录年度，是非常不可能的。”
Good health, good luck and much happiness throughout the year.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
6. Cancer Mortality Rate
A robust LinkedIn presence is crucial to any job search. You know that. Your manager knows that. And your manager probably knows that you know that – so she'll be concerned when you go from having a bare-bones profile on Monday to one jacked with additional work history, new connections, status updates and recommendations by Friday. "Don't go from zero to 500 overnight, because that can be quite obvious," Foss cautions。
Americans are celebrating Columbus Day Monday.Columbus Day is a federal holiday observed on the second Monday in October, marking the anniversary of the arrival of Christopher Columbus to the Americas. Columbus, an Italian explorer sailing under the Spanish flag, led four expeditions to the New World, but never accomplished his original goal -- to find a western ocean route to Asia. Instead, Columbus ushered in a new era in world history by opening up the Americas to exploration.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
9. The brain literally starts eating itself when it doesn't get enough sleep. Chronic sleep deprivation causes the 'clearing' process that usually happens when we sleep to kick into hyperdrive, prompting the brain to clear a huge amount of neurons and synaptic connections away.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Wishing you all the blessings of a beautiful New Year season.愿你拥有新年所有美好的祝福。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Attention, travel lovers. You may not have made any travel plans yet, but the choices for next year’s best destinations are already out. Recently, the well-known travel guide publisher Lonely Planet issued its Best in Travel 2014 selection. Here, we pick a few countries from its top 10 list to give you a taste.
“研究数据时，我不断回到这个问题上来，它其实是个身份政治问题，”挪威卑尔根大学(University of Bergen)研究欧洲极右翼党派的教授伊丽莎白?伊法斯夫拉腾(Elisabeth Ivarsflaten)说。“这是民粹主义者获得支持的最有力的征兆。”
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Here are the 10 bogies, drones targeting markets, stocks, bonds and the, global economy:
The gold market may be obsessed about the dollar and prospect of a rise in US interest rates. But there’s another factor looming on the horizon: a fall in gold mine supply.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
A happy New Year to you.
Officials with the State Administration of Press, Publication, Radio, Film and Television (SAPPRFT) said the film industry in China kept a steady development momentum in 2016 amid the "new normal" of the country's economic development.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Lufax, which started four years ago has emerged as the leader due to innovative credit rating techniques.
STEP 9: BE SURE to tell everyone to shut up on a daily basis, it's endearing you know
This marks the first time that Google has topped the list since 2011.
Who was buried here?
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The best bosses understand the art of delegation. My commenter said something along the lines of, “They’ve fired themselves from their previous job,” meaning that they don’t interfere in the day-to-day and minute-to-minute workflow or processes. In essence, learning to delegate instead of micromanage is about trust。
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
In 2011, at age 15, D'Aloisio closed a seed round of funding from Li Ka-shing. A year later, Summly launched, and within a month it had attracted 500,000 users and became the number-one news app in 28 countries. The Yahoo! sale capped off a remarkable run for someone not yet out of high school. But it's not mere technological savvy that sets D'Aloisio apart. Since long before he could shave, he has been driven by an intense curiosity and a desire to make some sort of mark on the tech world. Not just to create but to build and, yes, to monetize.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
The most popular surgical procedures include double eyelid surgery - which reduces excess skin in the upper eyelid to make the eyes appear bigger, lipoplasty - which uses high-frequency sound waves to eliminate fat - and nose jobs.
The first chart shows the total incidence of banking, currency and debt default crises in emerging markets since the 1970s, set against the nominal federal funds rate. Mr Koepke gives this as evidence that high and rising rates typically precede periods of EM crisis.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
7. Big anti-corruptionprograms will be accelerated. We expect to see increased prosecutions,from approximately 140,000 per annum today to more than 200,000 in 2014. Thisaggressive push for integrity and accountability will set the country on astrong new course. Success will become much more about what you know ratherthan who you know.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
The total amount of remittances, which is estimated to reach $450 billion in 2017, has risen by more than 50 percent in the past decade, IFAD said.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Developer: Frontier, Microsoft Studios
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
While not a low rating when compared to the other four dramas, it was still criticized by many audience members.
A modular microarray imaging system for highly specific COVID-19 antibody testing
8. It’s never too late to start.
Release date: 2015
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
PRICE PER SQUARE FOOT: $395
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
A recent example: When Gwen Stefani launched her new album Spark the Fire, Swyft created a free sticker pack and distributed it on several of its messaging apps. It was downloaded almost a million times and sent between users seven million times, resulting in 41 million impressions in 10 days. Such campaigns cost anywhere from $50,000 to $250,000 for brands, Wray says.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
February 1985 was the last time global surface temperatures fell below the 20th-century average for a given month, meaning that no one younger than 30 has ever lived through a below-average month. The last full year that was colder than the 20th-century average was 1976.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Nine out of the top 10 have all worked with Victoria's Secret in some capacity, with curve model Ashley being the only exception.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
节目30 相声，郭德纲 于谦
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
In truth, slower growth of about 8 per cent could be better for China and for the world. More environmentally sustainable and equitable outcomes would ease popular concerns and higher consumption would ease tensions over global trade.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Saif held the highest position among the five ranked Chinese schools, just ahead of Guanghua School of Management and Tsinghua University School of Economics and Management, 17th and 18th respectively.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
There are always one or two coworkers in the office that most people can't stand. But if you don't like most of your coworkers, chances are your days aren't very enjoyable because you have to work with them day in and day out. If you can't stand most of your coworkers, it's time to think about finding a company whose employees you mesh with better.
Experts offer advice for surviving -- and thriving -- in the next year:
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
伦敦商学院(London Business School，见上图)荣登2014年英国《金融时报》欧洲商学院排行榜榜首，该学院上一次夺得冠军宝座是在2005年。法国巴黎高等商学院(HEC Paris)和西班牙企业商学院(IE Business School)分列二、三位。
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Blue skies will not be, and should not be, a luxury.
Anti-HIV drug repurposing against SARS-CoV-2
Scientists may be working hard at making organs that match the body's capabilities, but why stop there?
Length-scale dependence of protein hydration-shell density
"There's a new type of wealth creation coming out," he told Reuters, adding China was having to adapt as the wider economy was "very materially slowing down".
伊法斯夫拉腾以英国独立党(U.K. Independence Party)为例，它的官方平台力主脱欧，但是面向选民的宣传中又强调移民对经济与文化的影响，她说这是一种混合了务实与民粹的论调。
Atlas Wearables founder Peter Li says battery technology and user retention are two more obstacles facing the wearables market. Some use cases require significant improvements to battery technology for a compelling experience, he says, and there’s always a balance to be struck between wear time between charges and processing power and features.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
“Who’s going to pay for that?” said Marc J. Luxemburg, the president of the Council of New York Cooperatives and Condominiums. “This has a real-world cost for many buildings.”
Among the top 50 richest women in the world, entrepreneurs from the Chinese mainland account for 56%.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Not every band can sound fresh 40 years into a career, but not every band is Blondie.
2013 Rank: 1
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