Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Do your homework. Read the assigned pages, and then some. Plug your topic into the Internet, grab another book at the library, and see what else you can learn about the subject.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Haub School of Business at Saint Joseph’s University in Pennsylvania is the only school ranked for the first time, in 98th place.
4. Precious metals: 'Going dark! Economic cycles point downward'
Trends and targets in antiviral phototherapy
We will endeavor to transform and upgrade traditional industries.
The dollar value of outbound shipments from China rose 12.3 per cent year on year in November, lifting from a revised pace of 6.8 per cent in October, and smashing a median forecast of 5 per cent from economists polled by Reuters.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Recipient: Their Royal Highnesses The Duke and Duchess of Cambridge (joint winners)
Trium is ranked first for the work experience of its alumni before the programme, second for aims achieved and third for international course experience. The programme is second for average salary ($307,003) of alumni three years after graduation, just behind the Kellogg/HKUST programme.
ACE2 as a potential therapeutic target for pandemic COVID-19
‘The Good Wife’ Once Will (Josh Charles), Alicia’s illicit love interest, died at the end of Season 5, this sexy CBS courtroom drama seemed as if it might droop and wither, but instead, the sixth season steamed with almost madcap energy, mixing Alicia’s newly fledged political campaign, a war of the roses between Alicia’s new firm and her old one, and the legal travails of Cary, her legal partner. Alicia isn’t quite so good anymore, and that makes “The Good Wife” all the better.
Diagnostic technologies for COVID-19: a review
Against: It might be that bit too far from the mainstream to make a huge awards impact.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Cheryl Boone Isaacs, Academy President
To make a long story short, the Seppenwolde group went bankrupt shortly after Christmas of 1772. The disaster was a top story in Dutch newspapers. It ruined some of Amsterdam’s merchants and bankers. To prevent a general credit collapse, the city of Amsterdam stepped in temporarily as a lender of last resort. Sound familiar?
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The first view is that the price is inherently cyclical. What has come down must go back up again and the deeper the trough the higher the next mountain.
During the summers, Good Humor ice cream trucks visit the company's campuses every other Friday during lunchtime. In the fall, cider and doughnuts are served twice a month, mid-morning.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
“New Yorkers have been waking up and realizing this long period of prosperity has wreaked a little bit of havoc on things that we think of as classic New York,” said Simeon Bankoff, the executive director of the Historic Districts Council, noting that 2015 will mark the 50th anniversary of the New York City landmarks preservation law. “Things we always thought were going to be there are just closing left and right.”
8. Smile every time EXCEPT when my team is losing.
Song “Fire In The Winter”(Kenji Wu and Dream Chorus)
Influenza neuraminidase: A druggable target for natural products
We will step up the development of public facilities in rural areas.
Foreign investment in emerging markets has dropped to the lowest level since the financial crisis as investors are braced for the fallout of the first US interest rate rise in nearly a decade.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The awards returned Ms. Lawrence, a winner last year for Russell's 'Silver Linings Playbook,' to the stage for an acceptance speech-something she said was no easier a year later.
The U.S. Veterans Day holiday also coincides with other World War One-era holidays around the world, including Remembrance Day in Britain and the Commonwealth nations of Australia and Canada.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
For over two decades I have been writing about the rise of Asia and the dynamic driving it. There is an extraordinary consensus among east Asian leaders that Asia needs to use this window of opportunity to focus on economic development and growth. War is the biggest obstacle to development. If Asians were truly stupid, they would engage in such wars and derail their enormous development promise. Most Asian leaders, barring North Korea, understand well the dangers of war. Hence, while there will be tensions and rivalries in the region, there will be no wars in the region, in 2014 or in 2015. As 2015 unfolds, I would like to encourage all western pundits to understand the underlying Asian dynamic on its own terms, and not on the basis of western preconceptions.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The media mogul is accused of blacklisting the actress after the meeting as well as deploying former Mossad agents to follow her and steal her memoir's manuscript.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
sc＝scene（n 风景），roll（n 卷）－卷着风景的画卷
妮妮·切利(Neneh Cherry)，《空白计划》(Blank Project)， Smalltown Supersound
A meditation on love, loss and the meaning of life. Dog people and Lou Reed fans will be especially susceptible (I plead guilty on both counts), but anyone who ever had a heart is likely to succumb to Ms. Anderson’s ethereal wisdom and her fierce formal wit.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
It is based on a survey of business schools and another of their alumni who graduated in 2013.
Inhibition of SARS coronavirus helicase by bismuth complexes
The clip, taken on a mobile phone, starts with the crowd singing the Frankie Valli lyrics: You're just too good to be true, can't take my eyes off of you'.
The best of 2015
4.Virtual Assistant: 17.6 percent increase
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The increase of these and other gases from human activity has caused the planet to warm by about 1.5 degrees Fahrenheit since the preindustrial era, which is causing land ice to melt all over the world. The oceans are rising at what appears to be an accelerating pace, and heat waves and torrential rains are intensifying.
这个领域的创新速度非常快。自从Fitbit于2008年成立以来，各家公司已经发布了五到六个完全不同的产品。三星（Samsung）则在九个月内发布了可穿戴设备Galaxy Gear的三到四个衍生产品。索尼（Sony）、Pebble、谷歌和Facebook的头戴式虚拟现实设备Oculus Rift也紧随其后。
A Method to the Madness
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
We learned about the causes and consequences of rising obesity around the world.
WHAT: A house with three bedrooms, two full bathrooms and two half-bathrooms
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
The website claims that "the more you sip, the smarter you (and the bottle) get," but in reality the more you sip, the drunker you get and the less information you'll retain.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
But the change in Wall Street’s — and Silicon Valley’s — appreciation of Mr Cook is down to more than just the 70m iPhones Apple is expected to sell this quarter or the $42bn in sales generated in the previous.
If Dwyane Wade lost 30 pounds of muscle, you wouldn't be able to tell him apart from the high school version of himself.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Sonneborn says he's been dismayed not only by what he sees as Trump's troubling decisions and juvenile moments but also by the president's response after a counterprotester was killed during the August white nationalist rally in Charlottesville, Virginia — which is what cemented Sonneborn's decision to seek office.
有趣的是，“真诚的问候”(unfeigned regards)又重回我们的视野——人们现在可以在印度服务中心的邮件上见到这一18世纪末的流行语。而更胜一筹的是这个签名，一个周五我收到了一则消息，末尾处写到：“周末好”(weekend well)。我差点将最佳名词使动用法奖也颁给它，不料最后一刻却杀出一匹黑马，一位顾问无意中说了句：“我们能把那件事冷毛巾一下吗？”(Can we cold towel that?)
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
6.You Spend Time Looking For Other Jobs
Any decision by China’s policymakers to begin selling down the country’s huge reserves would have a large impact on markets.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Yan Pu, head of portfolio review in Asia at Vanguard, suspects the Asian product mix may be holding things back. For example, Asian providers offer plenty of equity ETFs but very few fixed income products. In the US, she notes, fixed income ETFs are growing rapidly.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
In fact, academic research suggests that other economic and social transformations unfolding at the same time have led many people to anchor themselves more fully in their whiteness — even as whiteness itself has lost currency.
虽然唐尼主演的几部电影将在明年上映，但规模成本要比他的超级英雄电影小得多。直到2015年《复仇者联盟：奥创纪元》（Avengers: Age of Ultron）上映，他才能迎来下一个丰收季。
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
10. Neuroscientists have discovered a whole new role for the brain's cerebellum. It's long been assumed that the cerebellum functions largely outside the realm of conscious awareness, coordinating basic physical activities like standing and breathing, but it could actually play a key role in shaping human behaviour.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
这是两部后自语核(post-mumblecore)喜剧，讲述自我认知及其边界的故事。布西内斯克的影片是完美的怪人三角，三条边分别是盖·皮尔斯(Guy Pearce)、寇碧·史莫德斯(Cobie Smulders)和凯文·科利根(Kevin Corrigan)，以德克萨斯州奥斯汀怪人们轻松胡混的伪装出现。皮文的影片探索精神病以及日间电视节目的的黑暗疆域。由于克里斯汀·韦格(Kristen Wiig)的精彩演出（她饰演一个名叫爱丽丝·克里格的彩票得主），《欢迎来到我的世界》成了关于美国梦想者的精彩肖像，既令人不安，也鼓舞人心。
Thus it's rather a shock when you first encounter Nick D'Aloisio striding into London's Bar Boulud restaurant, firmly shaking hands and proceeding to outline his entrepreneurial vision. To imagine him in person, picture a Silicon Valley CEO blessed with an easy manner and 97th percentile media skills. Picture a guy who can confidently expound (while maintaining steady eye contact) on topics ranging from Noam Chomsky's theories to the science of neural networks to the immigrant mind-set to the Buddhist concept of jnana. And now picture this fellow trapped inside the gangly body of a British teen who might easily be mistaken for a member of the pop boy band One Direction-clad in a hipster T-shirt beneath a fitted blazer, hair swooping over his forehead, taking bites of a cheeseburger between bold pronouncements.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
The standout is "Him," a tear-jerker about queer love and cultural intolerance that, in its understated way, is an LGBTQ civil rights anthem.
James Bond 23 may still be quite a ways away from actually happening, as star Daniel Craig is commited to three chapters in the Millennium Trilogy, starting with the currently in-production The Girl with the Dragon Tattoo. There is currently no talk of hiring someone else to play James Bond, but if Craig is to reprise the role a third time, we still won't see James Bond 23 until 2014 at the earliest.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Hangzhou in Zhejiang Province and Shenzhen in Guangdong Province made the biggest progress in improving traffic with measures including vehicle restrictions and better road links, said the report.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Costco CEO Craig Jelinek
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
But researchers this year came up with a new method that makes flexible, realistic ears out of real cells. Those cells come from rats and cows, and they form a collagen gel that can take the shape of any mold. When placed in a mold of a human ear—a mold assembled using a 3-D printer—the gel forms an ear in less than an hour. The artificial ear then just needs a few days growing in nutrients before it's ready to be implanted in a subject.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Aoki-san is a pleasure to work withon storyboard. With Aoki-san on the team it feels like a sure thing. The visionof these animations will be perfect.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
9.Yeah, I was a badass on my high school football team! – Because I want to be seen by others in an even stronger light than I see myself。
A facile assay for rapid detection of COVID-19 antibodies
Meme-sharing Facebook groups have become a new college tradition, Mic reported last week, with students across the country trading inside jokes and fighting battles with rival universities via screenshot and caption.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
菲律宾参议院一委员会就国内发生的法外处决事件举行了听证会，罗纳德?德拉罗萨(Ronald Dela Rosa)在会上表示，自7月1日杜特尔特就任总统后，有712人在警方缉毒行动中被杀，还有1067起死亡正被作为与毒品相关的自告奋勇者杀人案件在调查中。
Elspeth Cheung, head of BrandZ valuation at Millward Brown, says: “The top 10 used to be dominated by consumer goods. This year, it’s technology.”
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Statistics show global research and development expenditure grew at an annual pace of approximately seven percent before 2009, but slowed down to four percent in 2014
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
This year's juries were chaired by AFI board of trustees vice chairs Tom Pollock (for film) and Richard Frank (for TV). Other jury members included Judd Apatow, Halle Berry, Jamie Lee Curtis, Leonard Maltin, authors and scholars representing prestigious universities with recognized motion picture arts and TV programs and film and TV critics from media outlets like NPR, Rolling Stone, TV Guide and The Washington Post.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
After weeks of rumors, Phil Jackson failed to move Carmelo Anthony and Derrick Rose, two players who absolutely should have been traded for the long-term benefit of the franchise.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
We’ve all had them: bosses and managers who make our work lives terrible and couldn’t manage a stack of paper clips, let alone a team of employees. I’ve written about the traits that make for bad bosses before, and in that article, a thoughtful commenter came up with his own list of what makes a good boss。
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
HOW MUCH: $2,050,000
Anti-HIV drug repurposing against SARS-CoV-2
'He does smoke cigarettes, he smokes many, many cigarettes.
Despite the fact that each market rebound ended up as a V-shaped affair, each successive rally was carried out with less and less individual stock participation. Glaring divergences between winners and losers, large caps and small caps, preoccupied the commentariat for most of the spring and summer. Deflationary concerns from Europe and the Japanese technical recession further confounded analysts, as Treasury yields and inflation indicators in the U.S. were driven lower despite the improving domestic economy.
Length-scale dependence of protein hydration-shell density
In a sign that civil service jobs may be losing their appeal, a report issued by recruitment website Zhaopin in late March said more than 10,000 public sector employees, including civil servants and staff members at public institutions, had submitted their resumes to potential employers through the site in just two months. The number was 34 percent higher during the same period last year, the report said.
The world's first flying bicycle flew on November 9, 1961, when Derek Pigott of the University of Southampton flew in a bicycle with an airplane-like body. It was called the Southampton University Man Powered Aircraft (sumpac). Derek furiously pedaled the air-bike to get it off the ground. It then flew 1.8 meters (about 6 ft) above the ground over a distance of 64 meters (210 ft). While the flight was short and slow, it still does not change the fact that it was the first bicycle to fly and at the same time, the first human-powered flight.
Graduates in economics and finance still have great prospects for making big money, the National Business Daily reported, citing a new survey. The average monthly salary for graduates from five major Chinese universities in finance and economics stayed above 10,000 yuan.
the Dutch lender that is a leading financier to farmers and agribusinesses around the world.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
7. “The Kindergarten Teacher” In his tough, weird knockout, the Israeli director Nadav Lapid spins the story of a teacher’s obsession with a child poet to create a savage portrait of fanaticism and its costs.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
This story pulls directly from the real Bling Ring gang , whose burglaries racked up $3 million over the span of ten months in 2008. All of the celebrities listed in the movie were real victims of this group, who claim to have been motivated by the "cultural obsession" surrounding celebrities' personal lives. Whatever their motives, the Bling Ring is a good reminder to take a step back from the media every once in a while.
It even featured in the March 19, 1870, issue of Scientific American magazine. Made by Thomas Luders from Olney, Illinois, and called a "pedespeed," the wheels then were much smaller, measuring around 36 centimeters (15 in) in diameter. Luders also said the skates could be used by anybody, irrespective of their physique. He himself was a large, heavy man, and he claimed he could use them for two straight hours without getting tired. Another version of wheel skates, appearing in 1923, had its tires on the inside of the foot rather than outside. (Other than the size of the wheels, the main improvement made by Chariot Skates is the small tire at the back of the bigger tire for increased stability.)
About this collection
2015年FT/麦肯锡最佳商业图书奖(2015 Financial Times and McKinsey Business Book of the Year)的获奖作品是《机器人的崛起：大规模失业的威胁与科技》(The Rise of the Robots: Technology and the Threat of Mass Unemployment)，这本书对工作自动化的未来做出了令人不安和常常令人消沉的分析。