Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
A total of 16 Chinese companies are in the top 100 on the list, including China Mobile, Alibaba and Tencent.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Does he have the ability to communicate his plans for what comes next—whatever they might be—to a fan base that's rightfully demanding answers after another ugly season on and off the court?
出手阔绰的美国公司正迫使英国同行提高从新入行者到顶级风云人物的薪资——尽管这并未阻止富尔德(Freshfields)的私募股权明星戴维希金斯(David Higgins)在圣诞节前夕跳槽到凯易律师事务所(Kirkland & Ellis)。精品专业律所通过提供更快、更专注的服务来吸引客户。
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Major American retailers including Wal-Mart, Target (TGT, Fortune 500), and Kmart all opened their stores on Thanksgiving to get a jump on the holiday gift shopping season. Wal-Mart even went as far as to open its stores two hours earlier this year than it did last. But Costco (COST, Fortune 500) refused to join the trend of "Black Friday creep" and kept its doors shut. Chief executive Craig Jelinek thought giving his workers a day off was more important than increasing his company's bottom line.
Trends and targets in antiviral phototherapy
n. 图形，数字，形状; 人物，外形，体型
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
“纽约人正逐渐意识到，这一漫长的繁荣期已对我们眼中的经典纽约市容造成了破坏，”历史街区保护委员会(Historic Districts Council)的执行董事西蒙·班考夫(Simon Bankoff)说，他同时指出，2015年将是纽约市通过《地标建筑保护法》的50周年。“环顾左右，那些总被我们认为是一成不变的东西，却都在纷纷关门闭户。”
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Airlines with operations based west of the Rockies boast the fewest flights that arrive late during the holidays, according to data compiled for Forbes.com by FlightAware.
If you are a working-class white person and you fear that the new, cosmopolitan world will destroy or diminish an identity you cherish, you have no culturally acceptable way to articulate what you perceive as a crisis.
ACE2 as a potential therapeutic target for pandemic COVID-19
Of the 200 nominated companies, 101 are privately-owned, while the rest are State-owned enterprises. The total value of these 200 listed brands has risen by 36 percent year-on-year to reach $696 billion, with the top 10 accounting for 46 percent of the total value.
A Larger Profile
Diagnostic technologies for COVID-19: a review
It was unearthed by archaeologists in 2012 and has since been kept at the Yizheng Museum. It is not shown to the public.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Banks, asset managers and insurance companies have flocked from mainland China to acquire prime Hong Kong office buildings, prompting the territory’s government to announce it will release more land for commercial redevelopment in the oversubscribed heart of the city.
Last question: a lot of thework you've donebrings out a lot of strong emotions in a way that it kind of questions themorality of heroism and justice. Is there anything related to you that makes us think of ourselves being a hero or yourself as one?
Concerns about the vulnerability of some emerging economies and gyrations in financial markets over the past few days should not dent “cautious optimism” about the global economy this year, leading central bankers and officials said on Saturday.
The number of country rankings published this year rose to 42, up from 38 last year. The newly featured countries are Argentina, Mexico, Pakistan and Romania.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
If we ask "What salary are you looking for?" say you're flexible, or say it depends on the responsibilities of the job. Try not to name a salary unless we really push you, because that gives us a leg up in the negotiating.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
China's Internet celebrities are estimated to create a whopping 58 billion market in 2016, far surpassing the 44 billion yuan in box office sales generated last year, according to an industry report.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
The workers, who were part of a crew building a football stadium, were taken in the mainly Shi'ite Habibiya district in northeastern Baghdad.
Antiviral drug discovery: broad-spectrum drugs from nature
Hello, I'm Severn Suzuki speaking for E.C.O. - The Environmental Children's Organisation. 大家好，我是Severn Suzuki，我代表儿童环境组织来此演讲。
Format: Classes meet every other week from Friday through Sunday in Evanston, IL, or once a month from Thursday afternoon through Sunday noon in Miami, FL
Influenza neuraminidase: A druggable target for natural products
Some of these people have instead reached for issues that feel close to their concerns: trade, crime, the war on drugs, controlling the borders, fear of Islamist terrorism. All are significant in their own right, and create very real fears for many people, but they have also become a means to have a public conversation about what society’s changes mean for white majorities.
A series of explosions on Aug. 12 that originated in a warehouse illegally storing hazardous chemicals in the port city of Tianjin killed 173 people, injured hundreds and left behind post-apocalyptic scenes of destruction. The blasts raised serious questions about the lax enforcement of safety regulations during China's rapid industrialization.
An investigation is continuing into how La La Land was wrongly named Best Picture rather than the triumphant Moonlight.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
We will perform with a strong work ethic, sense of responsibility, and enterprising spirit.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
改编自上世纪70年代真实贿赂事件的影片《美国骗局》当晚表现更加抢眼，埃米?亚当斯(Amy Adams)和珍妮弗?劳伦斯(Jennifer Lawrence)凭此片分获最佳女主角和最佳女配角奖。《为奴十二年》虽在提名数量上与《美国骗局》打平，参与了七个奖项的角逐，但当晚只摘得最佳剧情片一个奖项。
Remedy: This is another hindsight-based regret that you can’t cure without a time machine. The years, energy and dollars you spent on your degree are sunk costs. You can’t do anything about your past academic track record, but you can identify the areas in which you think you fell short in your college days and figure out how to augment those shortcomings in the present. For example, if you feel you didn’t do enough networking outside of the classroom, you might consider joining an alumni group or make a greater effort to participate in professional associations in your field. If you regret skipping your 8:00 AM managerial accounting class and mourn how useful those concepts would be to you now, check out the continuing ed options at your nearest community college.
Every four years, Allianz holds an international Olympics for its sports teams. The company covers the athletes' expenses and has an opening ceremony; in 2010, the games were held in Budapest with over 70 countries participating.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
“世界各地的政策制定者认识到美联储的决定将产生什么影响，为此忧心忡忡，这让我们担心，”百达资产管理公司(Pictet Asset Management)全球新兴债券部门主管Simon Lue-Fong表示。“人们在说美联储的决定已被反映到价格上，但既然没人知道究竟会发生什么，这怎么可能呢。”
The hair creates a resemblance to the look of Michelle Pfeiffer, but Ms. Chastain gives it more of an edge. Kay Georgiou, who frequently styles the hair of Matt Damon and Gwyneth Paltrow for films, oversaw the look.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
This Noah Baumbach Netflix film is both funny and award-worthy, which means you can feel really smart while you chuckle.
Negative emotions such as worrying, stress, depression and anger visit type D personalities more often. A small event that is usually overlooked by others can bother a type D a lot and even ruin his mood.
8) I am a closed kind of person 0 1 2 3 4
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Summly的一个早期版本──Trimit，于2011年7月出现在了苹果app store“新品推荐”栏目中。正是在这里，它被极具影响力的硅谷《科技博客》(TechCrunch)所关注，并迅速引起了李嘉诚的投资集团的注意。当达洛伊西奥收到李嘉诚的维港投资(Horizons Ventures)发来的电子邮件时，他只有15岁，并且基本没让什么人知道他所做的事情。在那之前，他从未与科技领域内的任何人物见过面，而他在Trimit的登记信息中也只是粗略形容自己是“伦敦的一家科技公司”。仅靠这一信息，谁也不会想到这家公司的管理和技术团队──事实上，它的全部职员──竟然是住在郊区卧室里的一个连车都不能开的小孩。
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Anyone who doesn't feel they can tap into their inner-Picasso to create amazing drawings needn't worry. The study demonstrated that it wasn't the quality of the doodles and drawings that helped participants recall given words. Drawing a simple outline of a banana offered just as much benefit to the memory as a perfectly drawn piece of fruit. Additionally, the study found that participants only needed to spend a few seconds on their drawing to receive a significant boost to their ability to recall the word. The researchers plan to take their research a step further in the future by introducing more complex words and ideas and measuring the memory success of participants asked to recall those intricate thoughts.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
According to Brandi Bennett at HostGator.com,maintaining a blog on a well-hosted website, or volunteering your time and skills, shows instead of tells the community, and thereby builds expertise and trust.
The proportion of enrolled female students has increased steadily since the ranking began six years ago to 42 per cent among the most recent cohorts. This is low compared with the 48 per cent of female students on masters in management courses but compares favourably with the 35 per cent in MBA programmes.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Gitanjali said she wanted to further refine the device so it could eventually go on the market.
Xinhua reported in 2015 that the MOE and five other central government departments were putting together a task force to ensure that football thrives in the country's schools.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
This is going to be one very interesting movie that shows the relationship between Captain America and Iron Man, who've always had trouble trusting each other.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
The film version of the popular television series "Legend of Sword and Fairy", also known as Chinese Paladin starts shooting in Zhejiang Province today.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Attraction: The adventure of a lifetime
Sport dominated the trending searches, with Euro 2012 and Olympic tickets showing the biggest rises in interest ahead of Houston and the Duchess of Cambridge.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Klay Thompson added 19 points and Andrew Bogut scored 13 for the Warriors, off to the best start by an NBA team since Dallas won its first 14 games in 2002-03. Golden State needs three wins to equal the league record of 15-0, held by the 1948-49 Washington Capitols and 1993-94 Houston Rockets.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Jackie Chan, a kung fu star and a member of the CPPCC National Committee, raised his experiences about smoking bans in China and Singapore as an example. During a business trip, his colleagues still smoked after a warning from a security guard in Zhuhai, Guangdong province, but they didn't dare smoke when they arrived in Singapore because "it was strict about smoking there".
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
年度故事将是纽约对911主谋穆罕默德(Khalid Sheikh Mohammed)的审判。
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Ladies and gentlemen, may I welcome you to the Bad Manners Awards 2016?
The worst of 2015
Wishing you all the blessings of a beautiful New Year season.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Wealthy Chinese bought at least seven overseas islands in 2014.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
1. You became a LinkedIn superstar overnight。
Honda hopes NSX will burnish its reputational halo for technical expertise. The automaker also wants NSX to help boost Acura’s brand image as a maker of premium cars and trucks. Last year, Honda’s U.S. sales rose 1% against a market that increased by 5.9% – resulting a loss of market share, most importantly, lost ground against its two main rivals, Toyota and Nissan.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Yes — by an eyelash. Democrats will need to win an additional 24 seats, meaning they will have to hold on to all 12 Democratic districts that Mr Trump won last year and pick up the 23 Republican districts that voted for Hillary Clinton, plus one or two more for good measure. The math is not on the Democrats’ side, but history is. The president’s party almost always loses some House seats in the midterms, and sometimes loses big, especially when the president has an approval rating below 50 per cent. See Barack Obama in 2010.
3. The root cause of eczema has finally been identified. Scientists have tracked down a series of proteins and molecular pathways that lead to this insufferable skin problem, revealing that the protein filaggrin isn't the sole culprit we thought it was.
You may already use Google Calendar, but are you using it wisely? Here’s a secret: only put stuff on your Google Calendar that will actually happen at that date and time. Use iPhone Reminders to remember things that are not time-sensitive (down to the hour or minute). Following this strategy will help you stay more sane.
A modular microarray imaging system for highly specific COVID-19 antibody testing
The sales volume peaks at around 15 million per day, with nearly 700 tickets sold in every second.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Yes, they hedge on the timing but the ticking time bombs are loud, close. And 'the precious-metals crash, starting in April of 2013, was the first warning of what is coming globally.'
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
“不能再采取某些国家先行动，其他国家随后行动的策略，因为时间不多了，”奥斯陆国际气候与环境研究中心(Center for International Climate and Environmental Research)的科学家格伦·P·彼得斯(Glen P. Peters)说。他也参与了这些新数据的编制。“现在需要大家齐心协力。”
里尔宁援引了荷兰经济政策分析局(CPB Netherlands Bureau for Economic Policy Analysis)的最新数据，数据显示，9月至10月经季节性调整的全球贸易量下降了1.1%，他表示，去年将被证明是世界贸易自2009年以来表现最糟糕的一年。
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
With both the S&P 500 and Nasdaq returning over 14% while the Dow and MidCap 400 each kicking in close to 10%, you would assume that passive investors would have an awful lot to celebrate this year. And indeed, they would have, if it weren’t for those pesky overseas stocks that did nothing but drag on the performance of any diversified portfolio.
Of course, Christian Bale won't be playing Batman, instead, a rather chubby Ben Affleck will save Gotham from the Superman.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
But the statistics bureau attributed the overall rise in CPI chiefly to a base effect resulting from low prices a year prior.
A facile assay for rapid detection of COVID-19 antibodies
Wishing you all the happiness of the holiday season.祝节日幸福如意。
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
●“Girl Infects 586 Men With HIV On Purpose, Plans On Infecting 2,000 More Before 2017 - TRENDING”
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
3. Flying Horse
In the past two decades, several campus poisoning incidents have sparked mass debates and concerns about students' psychological development and support.
The US remains home to the biggest brands and the value of its top 10 increased by 10 per cent to $1.3tn in 2016. The top 10 UK brands, headed by Vodafone, lost 8 per cent of their value. Those in continental Europe — led by Germany’s SAP software group — rose 5 per cent. Finally, the $360bn value of Asia’s top 10 brands, headed by Tencent, China Mobile and Alibaba, was only 10 per cent lower than the value of the top 10 in continental Europe and the UK combined.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Coca-Cola is in the middle of transforming its business as it sells off its bottling operations in the US and across the globe to focus on producing the concentrate that makes many of its drinks as well as research and development. Those sales will allow the company to focus more of its resources on innovation and acquisitions.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
4) I’m On It: You’re giving your full attention. You’re saying, “Relax. Don’t worry about a thing. I’ll see to it personally.” That response can disarm just about anyone. To express a deeper commitment, use “You have my word.” This makes you more accountable to someone, conveying that you’re on board and will make it happen…whatever it takes.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Employers have stepped up their hiring recently, adding 171,000 jobs in October and an average of 157,000 a month so far this year. That's a better pace than last year and the strongest job growth since 2006, Labor Department data show.[qh]
Length-scale dependence of protein hydration-shell density
Apple CEO Tim Cook
“…said he never lets people see him sweat — but he was sweating profusely.”
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
富达国际(Fidelity International)旗下全球地产基金的投资组合经理德克?菲利帕(Dirk Philippa)也削减了在香港的投资，把配置比重从两年前相对基准超配6%至8%调整至超配1%。
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Do you often feel gloomy and down in the dumps?
Having said this, don't make a pest of yourself. Nobody wants to hear you ask a question every 10 minutes. If you're completely lost, make an appointment to see your teacher after class.
About this collection
“The employee said she was going out to buy boots, but was never seen again.”