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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

A total of 16 Chinese companies are in the top 100 on the list, including China Mobile, Alibaba and Tencent.
电影迷们很快就能在北京国际电影节上庆祝一场视觉盛宴了,该电影节上还将放映近500部高质量电影。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Does he have the ability to communicate his plans for what comes next—whatever they might be—to a fan base that's rightfully demanding answers after another ugly season on and off the court?
出手阔绰的美国公司正迫使英国同行提高从新入行者到顶级风云人物的薪资——尽管这并未阻止富尔德(Freshfields)的私募股权明星戴维希金斯(David Higgins)在圣诞节前夕跳槽到凯易律师事务所(Kirkland & Ellis)。精品专业律所通过提供更快、更专注的服务来吸引客户。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 建筑建材业:涨价带来投资机会
Open Access Perspective

Soft matter science and the COVID-19 pandemic

中国会很快宣布一系列的关于房价调控和医疗保险的措施。在2014年,中国仍然需要建造7500万间超过7万5千美金的房产。这方面的投资,特别是医疗方面,使得普通中国消费者开始进入少存钱多花钱的消费习惯,进而促进内需,最终促进长期的就业增加。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

reflection

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

AdWords事实上是一个竞价排名系统,在支付费用之后,它会把客户的广告列在谷歌搜索结果和其他网站的靠前位置。只有当有人点击这些广告链接的时候,客户才需要支付费用。
Major American retailers including Wal-Mart, Target (TGT, Fortune 500), and Kmart all opened their stores on Thanksgiving to get a jump on the holiday gift shopping season. Wal-Mart even went as far as to open its stores two hours earlier this year than it did last. But Costco (COST, Fortune 500) refused to join the trend of "Black Friday creep" and kept its doors shut. Chief executive Craig Jelinek thought giving his workers a day off was more important than increasing his company's bottom line.
8Australia
伦敦商学院课程的一个主要优势是学员来自地域广泛的不同国家。其2015年MBA课程学员的90%来自海外,来自大约60个不同国家。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

该报道称,并没有老师和学生喝了有毒的水。
美国人星期一庆祝哥伦布日。每年十月第二个星期一是纪念哥伦布到达美洲的哥伦布日,属于联邦假日。意大利探险家哥伦布受命西班牙国王,四次率领船队探索新世界,但从来没有完成他最初的目标,也就是找到一条向西通往亚洲的海上航线。哥伦布为探险者开辟了美洲大陆,使世界历史进入一个新时代。
n. 图形,数字,形状; 人物,外形,体型
lace

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

“纽约人正逐渐意识到,这一漫长的繁荣期已对我们眼中的经典纽约市容造成了破坏,”历史街区保护委员会(Historic Districts Council)的执行董事西蒙·班考夫(Simon Bankoff)说,他同时指出,2015年将是纽约市通过《地标建筑保护法》的50周年。“环顾左右,那些总被我们认为是一成不变的东西,却都在纷纷关门闭户。”

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

n. 果心,核心,要点

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Airlines with operations based west of the Rockies boast the fewest flights that arrive late during the holidays, according to data compiled for Forbes.com by FlightAware.
If you are a working-class white person and you fear that the new, cosmopolitan world will destroy or diminish an identity you cherish, you have no culturally acceptable way to articulate what you perceive as a crisis.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Of the 200 nominated companies, 101 are privately-owned, while the rest are State-owned enterprises. The total value of these 200 listed brands has risen by 36 percent year-on-year to reach $696 billion, with the top 10 accounting for 46 percent of the total value.
A Larger Profile

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

纳粹势力席卷西欧,一场入侵迫在眉睫,然而一方面民众毫无准备,一方面国王还心存怀疑,认为王位陷入了自己党派设下的阴谋之中。丘吉尔必须承受至暗时刻,团结全国,改写世界的历史进程。
It was unearthed by archaeologists in 2012 and has since been kept at the Yizheng Museum. It is not shown to the public.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Banks, asset managers and insurance companies have flocked from mainland China to acquire prime Hong Kong office buildings, prompting the territory’s government to announce it will release more land for commercial redevelopment in the oversubscribed heart of the city.
Last question: a lot of thework you've donebrings out a lot of strong emotions in a way that it kind of questions themorality of heroism and justice. Is there anything related to you that makes us think of ourselves being a hero or yourself as one?
Concerns about the vulnerability of some emerging economies and gyrations in financial markets over the past few days should not dent “cautious optimism” about the global economy this year, leading central bankers and officials said on Saturday.
The number of country rankings published this year rose to 42, up from 38 last year. The newly featured countries are Argentina, Mexico, Pakistan and Romania.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

《2013全球幸福指数报告》出台的背景是,现在的人们要求政府和政策制定者能够少关心经济的增长,而花更多的精力在提高国民的幸福感上。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

经济学人智库表示,尽管没有一个北美城市进入前20名,但是纽约的生活成本相对于其他美国城市有所上升。纽约与洛杉矶并列第27位成为美国最贵城市。
If we ask "What salary are you looking for?" say you're flexible, or say it depends on the responsibilities of the job. Try not to name a salary unless we really push you, because that gives us a leg up in the negotiating.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
From the themed collection: 切实将“套路贷”关进法律笼子
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

China's Internet celebrities are estimated to create a whopping 58 billion market in 2016, far surpassing the 44 billion yuan in box office sales generated last year, according to an industry report.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

The workers, who were part of a crew building a football stadium, were taken in the mainly Shi'ite Habibiya district in northeastern Baghdad.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

“今年榜单有趣的地方之一是,尽管网站都开始实行更严的密码设定政策,位数少的密码仍出现在今年的榜单上。”
Hello, I'm Severn Suzuki speaking for E.C.O. - The Environmental Children's Organisation. 大家好,我是Severn Suzuki,我代表儿童环境组织来此演讲。
Format: Classes meet every other week from Friday through Sunday in Evanston, IL, or once a month from Thursday afternoon through Sunday noon in Miami, FL
调查指出,关键的是,世界的不稳定性和冲突可能继续推动通货膨胀并影响某些城市的生活成本。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
From the themed collection: 棚改降温对企业债的直接影响有限
Review Article

Influenza neuraminidase: A druggable target for natural products

Some of these people have instead reached for issues that feel close to their concerns: trade, crime, the war on drugs, controlling the borders, fear of Islamist terrorism. All are significant in their own right, and create very real fears for many people, but they have also become a means to have a public conversation about what society’s changes mean for white majorities.
到现在为止,要想准确可靠地检测到铅的存在,这都是非常昂贵的,同时这也意味着要发送样品,以用于分析。
A series of explosions on Aug. 12 that originated in a warehouse illegally storing hazardous chemicals in the port city of Tianjin killed 173 people, injured hundreds and left behind post-apocalyptic scenes of destruction. The blasts raised serious questions about the lax enforcement of safety regulations during China's rapid industrialization.
An investigation is continuing into how La La Land was wrongly named Best Picture rather than the triumphant Moonlight.
当瑞秋布鲁姆听闻自己赢得喜剧类电视最佳女主角奖项时,喜极而泣。亚马逊节目《丛林中的莫扎特》也意外斩获最佳剧集奖项。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

像考辛斯这样的超级球星以低廉的价格空降新奥尔良,并不只会帮助鹈鹕在新奥尔良雕刻出更大的运动景观,而且也是杰出的第一步。
We will perform with a strong work ethic, sense of responsibility, and enterprising spirit.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

authorization

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

塞舌尔

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 碧桂园推出家居装修“私人定制”
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

[iks'pi?ri?nst]
改编自上世纪70年代真实贿赂事件的影片《美国骗局》当晚表现更加抢眼,埃米?亚当斯(Amy Adams)和珍妮弗?劳伦斯(Jennifer Lawrence)凭此片分获最佳女主角和最佳女配角奖。《为奴十二年》虽在提名数量上与《美国骗局》打平,参与了七个奖项的角逐,但当晚只摘得最佳剧情片一个奖项。
Remedy: This is another hindsight-based regret that you can’t cure without a time machine. The years, energy and dollars you spent on your degree are sunk costs. You can’t do anything about your past academic track record, but you can identify the areas in which you think you fell short in your college days and figure out how to augment those shortcomings in the present. For example, if you feel you didn’t do enough networking outside of the classroom, you might consider joining an alumni group or make a greater effort to participate in professional associations in your field. If you regret skipping your 8:00 AM managerial accounting class and mourn how useful those concepts would be to you now, check out the continuing ed options at your nearest community college.
Every four years, Allianz holds an international Olympics for its sports teams. The company covers the athletes' expenses and has an opening ceremony; in 2010, the games were held in Budapest with over 70 countries participating.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

“世界各地的政策制定者认识到美联储的决定将产生什么影响,为此忧心忡忡,这让我们担心,”百达资产管理公司(Pictet Asset Management)全球新兴债券部门主管Simon Lue-Fong表示。“人们在说美联储的决定已被反映到价格上,但既然没人知道究竟会发生什么,这怎么可能呢。”
从碧昂丝和珍妮弗·洛佩兹的红毯着装来看,“短”是这次娱乐盛典的主题。这两位女歌手都选择及大腿的裙子来露出她们的美腿,策略性地减去领口,并注重肩膀的细节设计,但碧昂丝选择穿消防车红色从中脱颖而出,而珍妮弗·洛佩兹选择了柔和的有缎子般光泽的褐土色。
The hair creates a resemblance to the look of Michelle Pfeiffer, but Ms. Chastain gives it more of an edge. Kay Georgiou, who frequently styles the hair of Matt Damon and Gwyneth Paltrow for films, oversaw the look.
收入最高的十位模特中有九位都在内衣品牌维多利亚的秘密有相应的工作,大码模特阿什莉是唯一的例外。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

清华-欧洲工商管理学院的EMBA项目始于2007年,并于2012年进入英国《金融时报》排行榜,首次入围就直接冲至第四名。此后两年,该项目先后排名第二和第三,并最终在今年拔得头筹。
现任美国主席奥巴马的内阁共有7名女性,17名男性,克林顿曾是其中一员。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

This Noah Baumbach Netflix film is both funny and award-worthy, which means you can feel really smart while you chuckle.
Negative emotions such as worrying, stress, depression and anger visit type D personalities more often. A small event that is usually overlooked by others can bother a type D a lot and even ruin his mood.
考克斯说:“没人真正知道末日是什么样子的,上帝又会如何让末日降临。”
8) I am a closed kind of person 0 1 2 3 4
中美关系不仅会关系两国利益,而且涉及到地区和世界的和平安全稳定,我们要维护它前行。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
From the themed collection: 分析艺术涂料为何迎来热潮
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

这枚奖牌拍出的高价远远超过了该拍卖行预计的成交金额——5万美元到10万美元。此前,仅有1903年诺贝尔和平奖奖牌在1985年被拍卖,拍得将近1.7万美元。
(可可英语版权所有,未经允许请勿转载)
Summly的一个早期版本──Trimit,于2011年7月出现在了苹果app store“新品推荐”栏目中。正是在这里,它被极具影响力的硅谷《科技博客》(TechCrunch)所关注,并迅速引起了李嘉诚的投资集团的注意。当达洛伊西奥收到李嘉诚的维港投资(Horizons Ventures)发来的电子邮件时,他只有15岁,并且基本没让什么人知道他所做的事情。在那之前,他从未与科技领域内的任何人物见过面,而他在Trimit的登记信息中也只是粗略形容自己是“伦敦的一家科技公司”。仅靠这一信息,谁也不会想到这家公司的管理和技术团队──事实上,它的全部职员──竟然是住在郊区卧室里的一个连车都不能开的小孩。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

勇士的横扫,实际上让那些试图挑战勇士的球队无力追赶勇士的脚步,致使联盟在季后赛收入上损失惨重。于是,总决赛便成了战胜勇士的最后的希望,也是最后的机会。总有些愚蠢的人通过不断告诉你不要低估了勒布朗·詹姆斯来让你重燃希望。我看了所有五场詹姆斯在的总决赛,我现在客观的告诉你:詹姆斯知道自己赢不了。“我能做什么?他们赢了73场比赛,我打败了他们,于是他们引进了凯文杜兰特。”在凯文杜兰特用自己的冷血投射杀死系列赛之前,骑士还设法在三场比赛中夺得了一场胜利。但最后,骑士队虽然避免了横扫的尴尬,但他们结束赛季的方式也只能用虎头蛇尾来形容。
Anyone who doesn't feel they can tap into their inner-Picasso to create amazing drawings needn't worry. The study demonstrated that it wasn't the quality of the doodles and drawings that helped participants recall given words. Drawing a simple outline of a banana offered just as much benefit to the memory as a perfectly drawn piece of fruit. Additionally, the study found that participants only needed to spend a few seconds on their drawing to receive a significant boost to their ability to recall the word. The researchers plan to take their research a step further in the future by introducing more complex words and ideas and measuring the memory success of participants asked to recall those intricate thoughts.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

美国演员、作家、时装设计师、舞蹈演员、制片人、歌手——拥有这么多头衔的珍妮弗·洛佩兹是2015年全球十大美女的亚军。作为一个结过三次婚的女星,洛佩兹的感情问题一直都是世界各国媒体关注的焦点。除涉足娱乐圈外,她还在商业领域颇有建树,其中包括经营服装、配饰、香水等。此外,她拥有一家制片公司,主持电视节目,还成立了一家慈善机构。
According to Brandi Bennett at HostGator.com,maintaining a blog on a well-hosted website, or volunteering your time and skills, shows instead of tells the community, and thereby builds expertise and trust.
The proportion of enrolled female students has increased steadily since the ranking began six years ago to 42 per cent among the most recent cohorts. This is low compared with the 48 per cent of female students on masters in management courses but compares favourably with the 35 per cent in MBA programmes.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Gitanjali said she wanted to further refine the device so it could eventually go on the market.
Xinhua reported in 2015 that the MOE and five other central government departments were putting together a task force to ensure that football thrives in the country's schools.
读:口齿-教练要求口齿伶俐。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

This is going to be one very interesting movie that shows the relationship between Captain America and Iron Man, who've always had trouble trusting each other.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

The film version of the popular television series "Legend of Sword and Fairy", also known as Chinese Paladin starts shooting in Zhejiang Province today.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Attraction: The adventure of a lifetime
Sport dominated the trending searches, with Euro 2012 and Olympic tickets showing the biggest rises in interest ahead of Houston and the Duchess of Cambridge.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

他拿出教材,开始做起了家庭作业。
Klay Thompson added 19 points and Andrew Bogut scored 13 for the Warriors, off to the best start by an NBA team since Dallas won its first 14 games in 2002-03. Golden State needs three wins to equal the league record of 15-0, held by the 1948-49 Washington Capitols and 1993-94 Houston Rockets.
“尽管大多数中国品牌在国外还不为人知,但在国内,它们打下了很深的基础,”胡润百富董事长兼首席调研员胡润说。
Vawter 使用仿生腿在芝加哥一栋高楼里向上爬了103个阶梯,但是仿生腿的设计者们仍然在尝试提高它的性能。为了使它能适用于日常生活,设计者们必须让它更轻更薄。它的衍生品(充气仿生腿)可以满足陆军对于仿生腿的阶段性目标——行走一万步不用充电。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

q=Bjl(lzu,51yFuLz
金奇(James Kynge)

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 户籍改革提速 深挖增长潜力
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

“很显然,单独一个年度,即使是创记录的年度,不可能告诉我们很多关于气候变化趋势的东西,”德国波茨坦气候影响研究所地球系统分析部门主管斯德范·拉姆斯朵夫(Stefan Rahmstorf)说。“然而,有记录以来的最热年度是2014年、2010年和2005年的这个事实清楚地表明,全球变暖并没有‘在1998年停止’,像一些人喜欢错误地宣称那样。”
Jackie Chan, a kung fu star and a member of the CPPCC National Committee, raised his experiences about smoking bans in China and Singapore as an example. During a business trip, his colleagues still smoked after a warning from a security guard in Zhuhai, Guangdong province, but they didn't dare smoke when they arrived in Singapore because "it was strict about smoking there".

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

年度故事将是纽约对911主谋穆罕默德(Khalid Sheikh Mohammed)的审判。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
From the themed collection: 空调不能除甲醛
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

Ladies and gentlemen, may I welcome you to the Bad Manners Awards 2016?
The worst of 2015
由于欧元危机的影响,希腊,意大利,葡萄牙以及西班牙的排名大幅下滑。然而下滑幅度最大的是由于近期的政治危机影响的埃及,缅甸,和沙特阿拉伯。
Wishing you all the blessings of a beautiful New Year season.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

对胎儿进行手术有可能改变他们的人生。
Wealthy Chinese bought at least seven overseas islands in 2014.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

['pre]
1. You became a LinkedIn superstar overnight。
Honda hopes NSX will burnish its reputational halo for technical expertise. The automaker also wants NSX to help boost Acura’s brand image as a maker of premium cars and trucks. Last year, Honda’s U.S. sales rose 1% against a market that increased by 5.9% – resulting a loss of market share, most importantly, lost ground against its two main rivals, Toyota and Nissan.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

因特尔:新员工红地毯
去年年末,世界卫生组织宣布,寨卡病毒不再是全球紧急公共卫生事件。然而,人们才刚刚开始认识到这种病毒对婴儿及其未来几十年生活的影响。在巴西东北部,人们首次发现了病毒与小头畸形等出生缺陷之间的联系,家庭竭力为患病婴儿提供最好的生活。研究人员希望通过研究在巴西出生的一对双胞胎,来寻找病毒对胎儿影响的线索。这对双胞胎中,一个有出生缺陷,另一个没有。
安娜的头发比查斯顿本来的发色浅,有时安娜向后撩头发时会露出这两个层次,有点戏谑,但仍不失威严。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

为了缓解人口过多的问题,科学家研究出一项技术,可以将人缩小到只有5英寸高(12.7cm)。保罗(马特?达蒙饰)和妻子奥德丽(克里斯汀?韦格饰)决定把紧巴巴的生活抛在身后,自愿缩身加入一个全新的迷你社区。这一决定使得这对夫妇的人生发生了翻天覆地的变化。
[strein]

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

Yes — by an eyelash. Democrats will need to win an additional 24 seats, meaning they will have to hold on to all 12 Democratic districts that Mr Trump won last year and pick up the 23 Republican districts that voted for Hillary Clinton, plus one or two more for good measure. The math is not on the Democrats’ side, but history is. The president’s party almost always loses some House seats in the midterms, and sometimes loses big, especially when the president has an approval rating below 50 per cent. See Barack Obama in 2010.
3. The root cause of eczema has finally been identified. Scientists have tracked down a series of proteins and molecular pathways that lead to this insufferable skin problem, revealing that the protein filaggrin isn't the sole culprit we thought it was.
You may already use Google Calendar, but are you using it wisely? Here’s a secret: only put stuff on your Google Calendar that will actually happen at that date and time. Use iPhone Reminders to remember things that are not time-sensitive (down to the hour or minute). Following this strategy will help you stay more sane.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

The sales volume peaks at around 15 million per day, with nearly 700 tickets sold in every second.
《华胥引》

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

2012年,科学家开始认真寻找他的遗体。考古学家根据史书记载和地理线索,在一个市政停车场开始挖掘,并最终发现了遗骨。这里就是史书记载中埋葬查理三世的教堂的地点。
“我亲眼见到一个女人死了,并且我看到美国总统拒绝明确谴责杀害她的人。”
如果你在寻找一个免费的客户关系管理系统,Zoho或许正适合你。为什么呢?因为它提供了集成的可能性。比如只需添加你的API密钥,就可以轻松与JotForm和Unbounce集成。这意味着只需要几秒钟的时间,销售线索就可以自动发送到你的CRM系统。对于一款免费软件来说,这已经非常强大了。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Yes, they hedge on the timing but the ticking time bombs are loud, close. And 'the precious-metals crash, starting in April of 2013, was the first warning of what is coming globally.'

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 供需活跃 50城土地储备连涨12个月
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

“不能再采取某些国家先行动,其他国家随后行动的策略,因为时间不多了,”奥斯陆国际气候与环境研究中心(Center for International Climate and Environmental Research)的科学家格伦·P·彼得斯(Glen P. Peters)说。他也参与了这些新数据的编制。“现在需要大家齐心协力。”
里尔宁援引了荷兰经济政策分析局(CPB Netherlands Bureau for Economic Policy Analysis)的最新数据,数据显示,9月至10月经季节性调整的全球贸易量下降了1.1%,他表示,去年将被证明是世界贸易自2009年以来表现最糟糕的一年。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

当你在工作的时候,你的效率应该是很高的。不然的话,那就是在浪费你自己的时间和公司的财富。如果你很厌倦,一天当中大多数时间是在浏览网页,你可能是想要寻找其他的能够激励你的工作机会了。
4.Ask Questions

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

With both the S&P 500 and Nasdaq returning over 14% while the Dow and MidCap 400 each kicking in close to 10%, you would assume that passive investors would have an awful lot to celebrate this year. And indeed, they would have, if it weren’t for those pesky overseas stocks that did nothing but drag on the performance of any diversified portfolio.
Of course, Christian Bale won't be playing Batman, instead, a rather chubby Ben Affleck will save Gotham from the Superman.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

But the statistics bureau attributed the overall rise in CPI chiefly to a base effect resulting from low prices a year prior.
这项发明是伟大的,但也是愚蠢的。”这个开瓶器号称是“世界上第一个智能开瓶器”,但它不是突破性的。这个开瓶器能在你开酒瓶的时候通过短信发消息通知你的好友,这很疯狂,对吗?

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Wishing you all the happiness of the holiday season.祝节日幸福如意。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

和过去几年相比,2013年信心受到动摇的时候少了,但市场依然很容易受到影响。OppenheimerFunds的首席经济学家韦布曼(Jerry Webman)表示,虽然2013年的信心要强于以往,但全球各地也不都是这样。
7成以上受访者表示,实现自我价值是创业的最大动机。
别了,唐(Don)和他完美的西服;别了,佩姬(Peggy)和她的格子裙;别了,琼(Joan)和她的珠光宝气以及紧身连衣裙。
●“Girl Infects 586 Men With HIV On Purpose, Plans On Infecting 2,000 More Before 2017 - TRENDING”

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
From the themed collection: 盈利未达预期 龙湖冠寓换帅求变
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

我倒是并不担心费城、凤凰城和明尼苏达的球队。他们队伍都很年轻,都在重建的路上。如果他们能够取得进步,那很好,就算没有,他们也能获得高顺位的选秀权。而篮网队则是另一个故事了,我们稍后会讨论到他们。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: 中东LED照明灯具市场蓬勃发展
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

3. Flying Horse
In the past two decades, several campus poisoning incidents have sparked mass debates and concerns about students' psychological development and support.
The US remains home to the biggest brands and the value of its top 10 increased by 10 per cent to $1.3tn in 2016. The top 10 UK brands, headed by Vodafone, lost 8 per cent of their value. Those in continental Europe — led by Germany’s SAP software group — rose 5 per cent. Finally, the $360bn value of Asia’s top 10 brands, headed by Tencent, China Mobile and Alibaba, was only 10 per cent lower than the value of the top 10 in continental Europe and the UK combined.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

巴西
Coca-Cola is in the middle of transforming its business as it sells off its bottling operations in the US and across the globe to focus on producing the concentrate that makes many of its drinks as well as research and development. Those sales will allow the company to focus more of its resources on innovation and acquisitions.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

但是Jalava并没有拒绝医生的建议(出于伤情的实际情况考虑,拒绝很困难),而是将这个建议作为自己的期待。他决定试一试,并且真的在植入的手指里放入两千兆字节的数字存储器。他现在只需将指甲剥掉,露出USB插头,即可将手指插入电脑连接。他也可以在任何时候拿掉整个手指,并且借给朋友使用。
4) I’m On It: You’re giving your full attention. You’re saying, “Relax. Don’t worry about a thing. I’ll see to it personally.” That response can disarm just about anyone. To express a deeper commitment, use “You have my word.” This makes you more accountable to someone, conveying that you’re on board and will make it happen…whatever it takes.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
From the themed collection: 丝绸经济带为建材业带来发展机遇
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

7.别问警察怎样去伦敦西区最快,也别问他如何使用牡蛎交通卡。他也很想帮你,不过他是从西米德兰兹郡来的。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

2015年,中国各大银行的盈利有所萎缩。在这一年里,中国银行业经历了央行的几轮降息,并在中国政府取消存款利率上限之后发现,轻松赚钱的时代结束了。
肥皂剧通常都在电视收视排行榜上位居前列,但2012最流行的电视节目是英国广播电台儿童节目《麦克小骑士》,它打败了美国惊悚电视剧《国土安全》和真人秀节目《Towie》。
Employers have stepped up their hiring recently, adding 171,000 jobs in October and an average of 157,000 a month so far this year. That's a better pace than last year and the strongest job growth since 2006, Labor Department data show.[qh]

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

另一方面,2月PPI同比下降4.9%,低于1月5.3%的同比降幅。2月PPI降幅为8个月以来最低降幅。
恭祝新年吉祥,幸福和欢乐与你同在。
Apple CEO Tim Cook
“…said he never lets people see him sweat — but he was sweating profusely.”

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

富达国际(Fidelity International)旗下全球地产基金的投资组合经理德克?菲利帕(Dirk Philippa)也削减了在香港的投资,把配置比重从两年前相对基准超配6%至8%调整至超配1%。
rob

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

卓越雇主排名:7
Do you often feel gloomy and down in the dumps?
Having said this, don't make a pest of yourself. Nobody wants to hear you ask a question every 10 minutes. If you're completely lost, make an appointment to see your teacher after class.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

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['kw?lifaid]
“The employee said she was going out to buy boots, but was never seen again.”

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