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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

administration
大学的工作人员表示这封信已经伴随学校的意见T恤一起送往Siddeeq先生了。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Goldie Blox是一家玩具公司,使命是重新定义玩具商店中的“粉红走道”。在科学、技术、工程和数学(STEM)教育和职业领域,男性数量要大大多于女性,大部分女孩往往在八岁前就对这些领域失去了兴趣。Goldie Blox所设计的玩具则通过吸引女孩发展强大的口头及故事讲述能力的方式——同时仍提供机会来发展日后可转化成对工程学兴趣的技能——来鼓励和启发未来的工程师们。说到机会,一家玩具初创企业如何能在和一开始就统治着玩具行业的大公司的抗衡中脱颖而出呢?Goldie Blox走出了明智的一步:最近,该公司发布了一段视频,采用了Beastie Boys的歌曲《女孩们》(Girls)做背景音乐,该视频得到了病毒式传播。尽管这段视频最终被撤下,但Goldie Blox在提高公众对让更多女性和女孩对STEM产生兴趣——以及对Goldie Blox玩具——的认知上,做了一份相当不错的工作。
选择出国继续学习的学生比例也出现小幅下降,由去年的4.8%下降至3.4%。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

It's a bit of a lark organised by UK film critics – a gong for the top canine performance at the festival, handed out on the last Friday in the British pavilion. This year the Palm Dog went to Lucky, a Maltipoo – that's half Maltese terrier, half poodle – who plays Dixie in Miguel Gomes' six-hour epic, Arabian Nights. The prizewinner is presented with a toy bone and this year delivered a brief acceptance speech (“woof”) by video link. A jolly time was had by all but an unnamed French journalist felt that the award was “an unwanted intrusion of British silliness” in the glamorous proceedings, according to AFP. “From the French perspective, this is a bit bizarre,” he is reported to have said. “The British are weird.”

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

The survey is based on costs of over 160 items ranging from food and clothing, to domestic help, transport and utilities.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

On Tuesday, 17-year-old Thomas Sohmers unveiled a new super fast computer server that uses a fraction of the electricity that a normal computer does.He's showing it off at the Open Compute Project (OCP) Summit happening this week in San Francisco.This computer is the first product from Sohmers' startup, REX Computing, created with 52-year-old co-founder and CTO Kurt Keville.
IE商学院的在线MBA持续吸引着高素质的学员。其半数校友在入读时为高管级别,为所有上榜学院中比例最高的。该学院的在线MBA学员在毕业3年后的平均年薪最高,为17.9万美元,比薪资排第二位的(巴布森学院(Babson College)奥林商学院(Olin Business School))高出约3万美元。
A woman's portrait has not been printed on U.S. paper money since 1896, when Martha Washington, the wife of the first U.S. president, was shown on a one dollar silver certificate.
本次伦敦奥运会,中国队派出了焦刘洋和刘子歌的双保险参加女子200米蝶泳比赛。刘子歌是北京奥运会该项目冠军,并且保持着世界纪录的头衔,焦刘洋则是北京奥运会亚军,去年上海世锦赛冠军。从报名成绩来看,焦刘洋和刘子歌排名也都靠前,女子200米蝶泳将是中国泳军在伦敦奥运最有把握夺金的项目之一...

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 吸音涂料的施工及注意事项
Perspective

Trends and targets in antiviral phototherapy

But we at The BostonConsulting Group believe that the current dip in China’s growth will not endureand that, under Xi’s leadership, China’s economy is destined to continuegrowing at a rapid clip. In fact, we are confident last week’s reforms willcontribute mightily to China’s growth between now and 2020. We stand by our base case forecast that China will deliver$4 trillion in growth over the next decade and combine with India to deliver a$10 trillion prize — an economic powerhouse driven by booming middle classconsumption and growing overall optimism. No one can perfectly forecastthe future … and in our book we describe scenarios where growthslows. But we remain optimistic and positive about China’s future.
An employee in the public relations department at Tencent Holdings, operator of a live-broadcast app through which a man received online payments of more than 250,000 yuan ($36,400) from a 13-year-old girl for his singing talent, said the girl might have faked her age when registering.
有的时候,老板挺糟糕的。但如果你觉得你的老板一直很差劲,占用了你的时间,是的,你该去找一份新的工作了。
In interviews, everyone works well with others, and everyone learns quickly. Please tell me something else.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

THE AMERICANS (FX, Jan. 28) Season 3 of this terrific blend of Cold War spy thriller and family drama begins with Washington’s K.G.B. contingent feeling the weight of the Soviet war in Afghanistan. Frank Langella joins the cast as the new handler for the show’s husband-and-wife agents, replacing Margo Martindale’s Claudia. (Making its premiere eight days later: NBC’s “Allegiance,” about Russian spies embedded in the United States. Huh.)

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
From the themed collection: 乡村振兴“样板化”走不远
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

[ni'glekt]

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

But the developments also point to the vast gap in the use of such cases between the US and EU, where a debate is under way over whether to grant China “market economy” status in the World Trade Organisation, a concession that would make it even harder to bring anti-dumping cases.
The app D'Aloisio designed, Summly, compresses long pieces of text into a few representative sentences. When he released an early iteration, tech observers realized that an app that could deliver brief, accurate summaries would be hugely valuable in a world where we read everything-from news stories to corporate reports-on our phones, on the go. The app attracted the interest of investors around the world, ranging from Hollywood celebrities to Hong Kong billionaire Li Ka-shing, the wealthiest man in Asia.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

根据电视网的预测数据,奥巴马在大选必争之地的摇摆州俄亥俄州取得了胜利,而这使得他在大选之战中获胜,获得了超过当选总统所需的270张选举人投票,也终结了罗姆尼在一系列的摇摆州混战中燃起的希望。
This 1977 file photo shows Apple co-founder Steve Jobs as he introduces the new Apple II in Cupertino, Calif.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

7、Bad body language habits
单词check 联想记忆:

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

toxic
Cheng further says, "once you find a list that fits your needs, just tap on the list to see suggested locations. Then swipe right or left to see more options and tap 'read more' or the arrow at the bottom of the screen to select a venue and get more details.".
在假日旅行最佳航空公司的排行榜上,夏威夷航空公司(Hawaiian Airlines)遥遥领先,紧随其后的是另一家主要经营太平洋海岸业务的阿拉斯加航空公司(Hawaiian Airlines)。相反,根据FlightAware的数据显示,假日旅行期间最差的航空公司是总部位于纽约的捷蓝航空公司(JetBlue Airways),经营区域航线的快捷航空(ExpressJet)排名倒数第二。
不过,这一涨幅显著低于此前一个月8.2%的环比涨幅。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

infect+ion→传染;感化

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
From the themed collection: 三方齐发力 防范房地产市场风险
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

6.Head-Mounted Computer Displays
circulation

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Common 和 Day 将会演绎电影《马歇尔》中的歌曲《Stand Up For Something》还有Settle会演唱电影《马戏之王》中的歌曲《Thisis me》。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

While the political system will be fixated on preserving stability as new leaders take the helm, reduced economic flexibility could thwart Beijing's intentions to do so.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

Jonathan Glazer’s Under the Skin is a film about a beautiful, scary alien that is itself beautiful and scary and alien: it’s an entirely extraordinary, outrageously sensual film that Glazer’s previous excellent work had really only hinted at, partially and indistinctly. His Sexy Beast (2000) was a visually accomplished, exciting and intelligent crime thriller that was way ahead of the woeful mockney-geezer mode of the time. Birth (2004) had Kubrickian ingenuity and chill, with some remarkable moments; it was a movie that deserves cult-classic status but has yet to achieve it. Then a decade went by, and it seemed that Glazer might be a stylist for whom a sustained cinema career would perhaps not be achievable (and heaven knows, it can happen to the most talented).
1. 詹妮弗?劳伦斯
'I think the situation will somewhat moderate in future as society becomes more diverse. But it will take quite a bit of time until we get there,' he told the reporters.
葡萄牙完全使用可再生能源供电四天

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

很多宏伟壮观的博物馆坐落在布鲁日、安特卫普和布鲁塞尔等风景如画的城市中。艺术爱好者可尽情徜徉在中世纪时期的大量艺术瑰宝中。同时,你也不要错过造访宁静小镇、参观哥特式建筑的机会。比利时拥有世界上最好的啤酒、巧克力以及薯条,因此,在那里人人都是美食家。随着第一次世界大战爆发100周年纪念日的临近,未来几年,比利时将成为更多游客的首选。
9) Well Done: It’s a cliché, no doubt. Sometimes, it isn’t enough just to say thanks. People want to know what they did was great and why. They pour so much sweat and soul into their projects.They need to know their work was special and had meaning to someone.
反对:影片可能太过非主流,不具有获得大奖的影响力。
It is just a common sense that no one wants to see chaos at his doorstep.
玛戈特·瓦尔斯特伦在20多岁时结束了一段充满暴力的感情。作为外交部长,她正在一个传统上属于男性的领域里挑战各种假定。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

For the fourth year in a row, the top five places continue to be dominated by the same five intercontinental EMBAs. Tiemba came top this year not by spectacularly outperforming its rivals but thanks to a strong performance across most indicators. In particular, the alumni have the second highest salary on average ($324,000) behind alumni from the Kellogg/HKUST programme ($408,000). Tiemba is also ranked second for career progression and fourth for work experience.
8.Yes Man

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Few years in recent decades dawned with as much of a sense of pessimism as 2014. One consistent theme in the predictions for the year was that 2014 looked eerily similar to 1914. Most pundits predicted doom and gloom, especially in east Asia. Yet, while there were many horrific events — from thedowning of flight MH17 over Ukraine, to the abduction of hundreds of schoolgirls in Nigeria and the rise of the Islamic State of Iraq and the Levant — we have avoided outright world war. Now that the year is closed, with no repetition of 1914, it may be wise to investigate why the pundits were wrong, particularly on their ideas around the potential for conflict in Asia.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

他说:“目前为止,健身追踪器还不属于这类产品。但是下一代可穿戴设备有潜力跨越这个至关重要的里程碑。”

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

This makes China the leader among middle-income economies for this indicator, followed by India which has overtaken Brazil, according to the report jointly released by Cornell University, INSEAD and the World Intellectual Property Organization (WIPO).
Nirvana in Fire unexpectedly achieved a tremendous success, rising like a star among the TV dramas in the fall of 2015. Also adapted from an online novel of the same name written by Hai Yan, the adaptation for the first time found its way on the screen in September 2015. Staring Hu Ge and Liu Tao, the series shows a talented military strategist endeavoring to clear his name through continuous fights. The fictional characters and dynasty let the adaptation smartly avoid being criticized for not sticking to historical accuracy. And the drama`s delicate internal settings and impeccable storyline were highly praised by the audiences.
Among French schools, Toulouse Business School made the best progress, up 14 places, after featuring in the Executive MBA ranking for the first time.
能够再次主持奥斯卡我感到非常激动和荣幸。你知道有句老话:第三次总是幸运的。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

The wealth and depth of knowledge from around the world adds tremendous value to the course, wrote another graduate from the US, adding that “with so many cultures and experiences represented, a classroom ethics discussion about bribery is not your typical boring USA version”.
Landing a superstar like Cousins for pennies on the dollar won't singlehandedly help the Pelicans carve out a larger slice of the sports landscape in New Orleans, but it's an excellent first step.
周二早些时候,吕特呼吁在与土耳其的争执中保持冷静。
1. “The Assassin” and “Mad Max: Fury Road” (tie) Hou Hsiao-Hsien and George Miller directed the year’s two best commercial movies, both of which should be seen on the biggest screen you can find.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

单词consciousness 联想记忆:
China saw its population grow last year, along with an improved male-female ratio and the level of education, according to a survey from the National Bureau of Statistics that was released on last Wednesday.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

《the Post》
201312/270511.shtml重点单词
乔斯·威登在度假的时候萌发了创作《萤火虫》的设想。他当时正在读一本叫做《天使杀手》的书,这本书讲述了一名葛底斯堡战役中的士兵的故事。威登深深地被这个士兵日复一日的艰辛生活所吸引。这本书的作者描写了大量日常生活中的繁琐细节,以及人们如何在缺乏现代科技和商业之便的情况下艰难度日。而威登对这种描写方式推崇备至。
瑞典
n. 前辈,前任,原有事物

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

位于第三位的是收入5.95千万的Fleetwood Mac,尽管这支乐队有三位男士,它也以拥有两位备受瞩目的女星为荣,她们是史蒂薇.妮克丝和最近回归的克莉丝汀麦克,是她们造就了本次上榜。乐队的巡回演唱会On With The Show在打分期间共有86场演唱会,在每个城市平均挣得超过1百万。
Ahh, the glamorous life of AT&T: best friends with Steve Jobs, exclusive rights to the iPhone (for now) and carrier of choice on the iPad. So why, with everything going for it, did the stock miss a huge rally? In the year ending April 1, Apple soared 109% and the S&P 500 rose 41%. AT&T? Down 2%. The problem is growth, or lack thereof: little in its saturated wireless business and a decline in landlines, which still accounts for 25% of sales. Unless its high-speed Internet business takes off or the iPad drives new wireless growth, the beatings by Wall Street will continue.
9) Well Done: It’s a cliché, no doubt. Sometimes, it isn’t enough just to say thanks. People want to know what they did was great and why. They pour so much sweat and soul into their projects.They need to know their work was special and had meaning to someone.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

5.3-D 打印耳朵
二十多年的旨在减少温室气体排放增长的全球谈判几乎没有进展。但在2014年,人们看到了针对这个问题的大规模政治行动的迹象,在30多万人去年九月在纽约举行大游行之后,世界各地的其他城市中也有数以万计的人走上街头。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

本文为与《创业者》杂志的合作内容。下文最初发表于Entrepreneur.com。
在10月份的第三场总统大选辩论中,两位总统候选人没教养地拒绝与对方握手问好或道别。
1.无论在什么情况下都不要问出租车司机,对于今年夏天伦敦的奥运会有多么激动。不是说他会勉强或尴尬地发表个人意见,而是你根本就不该问这个问题。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

会是除巴西、德国和西班牙之外的国家捧得大力神杯吗?
美国仍是最具价值品牌大国,2016年该国10强品牌的品牌价值增长10%,至1.3万亿美元。以沃达丰(Vodafone)为首的英国10强品牌的品牌价值缩水8%。以德国软件集团SAP为首的欧洲大陆10强品牌的品牌价值增长5%。最后,以腾讯(Tencent)、中国移动和阿里巴巴(Alibaba)为首的亚洲10强品牌的品牌价值达3600亿美元,仅比欧洲大陆和英国10强品牌的品牌价值总和低10%。
2016年的年度色彩与以往不同,它是两种颜色的组合:粉水晶(Rose Quartz,一种矿物粉色)和宁静蓝天(Serenity,一种淡蓝色)。在该公司的网站上,这两种颜色浑然融为一体,看不清它们的界线。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

摩根士丹利的分析师乔纳斯认为,Model X的销量将会更加可观,但不是由于它的燃油经济性,而是它升级后的信息娱乐系统,以及独特的“鹰翼”式后车门。他还表示,如果Model X没有赢得所有的年度车型大奖,他会非常失望。他并不是唯一一个这样想的人。埃隆o穆斯克和其他很多祈祷特斯拉继续保持当前势头的人当然也会这样想。(财富中文网)

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

At the center of the speculation is BlackBerry’s healthy intellectual property portfolio, 44,000 patents and still growing. Last October, for example, the company won at least 27 new ones—covering everything from conference-calling interfaces to touch screens to security features for wearable technologies such as smart watches, eyeglasses and fitness bands. Security continues to be BlackBerry’s biggest selling point with businesses. Just ask the Sony movie studio division, which “resorted” to outdated BlackBerrys to restart communications after its security breach last Thanksgiving.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

The World Health Organization this year declared H1N1 a global epidemic. Fortunately, it is much less threatening than people previously believed, and newly introduced vaccines seem to have quelled lingering fears.
Cullinan and Ruiz each carry a suitcase containing a copy of the winning envelope for all the categories - meaning there are two envelopes for each award.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
From the themed collection: 定制家居PK 上半场已经结束了?
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

She argues, however, that the problems with lower liquidity of ETFs in Asia are a symptom of a fund distribution system that fails to incentivise ETF sales by intermediaries. “I don't think there is a quick fix, but you would see a pick-up if Asia moves to a fee-based model,” she says.
7. The legacy of a celebrated neuroscientist is contested
5. Fan Bingbing - $17 million
年度最佳单曲:米兰达·兰伯特《Over You》

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

网上的撤稿公告共列出了107篇论文及524位作者,他们几乎都是中国临床肿瘤专家。所涉及的医院都是顶级公立机构。
democratic

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 石材行业如何淘汰落后产能
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

To see that businesses and the public benefit more from our reforms to streamline administration, delegate powers, and improve regulation and services, we must cut red tape, level the playing field, provide greater convenience, and remove that last crucial hurdle.
7. “飞翔莲花”(Flying Lotus),《你死了》(You’re Dead), Warp。新融合乐绝不会对旧融合乐说抱歉,这只是升级而已。身为制作人的“飞翔莲花”既注重延续性,也注重破坏、模糊之美与跳跃剪辑的喧闹。他对死亡的组曲式沉思为不虔敬的智慧留出空间,《永远不能抓住我》(Never Catch Me)这首歌的歌词由肯德里克·拉玛(Kendrick Lamar)创作,堪称年度最佳。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

According to file-sharing news site TorrentFreak, "Game of Thrones" has an estimated 5.9 million downloads per single episode. That number does not include online streaming and cyberlocker downloads, which would make the figure significantly higher. By contrast, "Game of Thrones" has an estimated 5.5 million TV viewers per single episode。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

Saif held the highest position among the five ranked Chinese schools, just ahead of Guanghua School of Management and Tsinghua University School of Economics and Management, 17th and 18th respectively.
As for bitcoin in the mainstream banking system? “We are still a good year away, in our estimation, from where you can imagine a known financial services company using this,” Ludwin says. “But it’s not 10 years. And when it happens, people will be surprised by how quickly it spreads.”
此外,该专家补充说道,受当前经济形势的影响,并且我国金融市场资源重新配置,银行业高速增长的周期已经过去。
如果美国汽车行业杂志《沃兹汽车》(Wardsauto)的专家最新编撰的最佳引擎榜单可作为一种指示,那么在当代轿车、卡车和跨界车的引擎盖下面正发生一场静悄悄的革命。涡轮增压、机械增压和柴油引擎——甚至还有一款电动发电机——主导了第20届年度十大最佳汽车引擎奖;根据《沃兹汽车》,这些奖项“表彰了杰出的动力系统成就、世界级技术以及那些帮助推动汽车销售的稀有发动机或者电力推进系统。”

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

6.Gal Gadot
Unlike MBAs, masters in management are targeted at those at the beginning of their career.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

8. Greenland sharks live for a very long time
他补充说道:“我很兴奋能有机会重返中国,并享受这个国家的文化以及把NBA现场比赛的激动直接带给中国球迷。”
n. 所有权

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

国际移民组织说,2015年进入欧洲的移民和难民数量已超过一百万,为二战结束以来最大的移民潮。
祝大家2015年好运。(财富中文网)
The book reflects growing anxiety in some quarters about the possible negative impact of automation on jobs, from manufacturing to professional services. The subtitle of its UK edition warns of “the threat of mass unemployment” and, in the US edition, foresees “a jobless future”.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Zuckerberg, 31, had the best year of all billionaires, having added 11.2billion dollars to his fortune and moving up from number 16 to six on the list. This is Zuckerberg's and Amazon's Jeff Bezos' first appearance in the top ten of Forbes' annual ranking.
Imports grew 3.1 per cent year-on-year in dollar terms to $168.6bn in December after growing a revised 4.7 per cent (previously 6.7 per cent) the previous month. That rate was roughly in line with a median forecast of 3 per cent growth.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
From the themed collection: 大病保险报销比例由50%提高至60%
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

这句简练、言之有物、几乎可称之为妙语的话提醒我们,即便接下来的奖项都相当雷人,还是有人能够做到直白的。
Forever pop's Number One rebel, Charli XCX returned with an excellent surprise mixtape.
流行音乐界永远的一号叛逆者夏洛特·艾玛·艾奇逊带着一张出色又令人惊讶的混合专辑回归了。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

“If lenders are too optimistic during market booms and too pessimistic in downturns, that could be a good reason for authorities to set conservative capital requirements,” he suggests. “Higher haircuts might dampen the initial run-ups, but they could also dampen the subsequent fallouts when tides turn.”
A report on entrepreneurship among Chinese college students published by Renmin University of China revealed an inverse proportion between the level of students' academic degrees and their intentions to start their own businesses.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

《剧集人生》(Episodes):映时频道的这部喜剧经常被忽视,它讲述的是两位被困在好莱坞的英国电视编剧在为马特·勒布朗(Matt LeBlanc)创作电视剧时遇到的困惑。勒布朗在剧中饰演他自己,演得很精彩。以娱乐业为背景的电视剧很少能保持最初的巧妙构思,但这部剧的第三季比前两季还要精彩。
中国早已超越了俄罗斯成为紧随美国之后的世界第二大强国。
9.亲爱的贵客们,我们希望英国能为你们贡献一个美好的夏天,这个夏天包括了顶尖的国际赛事、先进的设施、有趣的娱乐、以及汇集了几个世纪的艺术建筑精华的文化遗产。如果你最终只收获了四张卓著国际中心的摔跤比赛门票,好吧,祝你下次好运。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Stock pickers encountered difficulty this year in part because of concentration at the top of the market. Just five stocks—Apple, Berkshire Hathaway, Johnson & Johnson, Microsoft, and Intel— accounted for 20% of the market’s gains. If you weren’t at least equally weighted toward them, you had virtually no shot at making up for missing their enormous, index-driving gains. A majority of the market’s stocks did not perform nearly as well. According to the Leuthold Group, only 30% of S&P 1500 stocks posted gains exceeding the index itself. You’d have to go back to 1999 to see anything like this.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
From the themed collection: 中科院大气所两个项目落户乐亭
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 家居产品深陷环保质量漩涡
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

各类公司均表示要扩充高级系统分析师队伍。与今年的薪酬水平相比,这一职位的起薪预计会增长5%,达到8.55万美元;大型企业中,金融分析师的起薪将达到8.15万美元,比2010年增长4.8%;经验丰富的行政助理的薪水也将上涨3.1%,达到4.175万美元。
Apple Inc., Alphabet Inc.'s Google, and Coca-Cola Co. topped the list of the world's 100 most valuable brands in 2016, while technology and automotive brands dominated the overall rankings, according to a new report from brand consultancy Interbrand.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

How has your trip to the US sofar this summer?
教育部还表示,公费留学学生的归国率达到了98%。公费留学生一般选择中国急需的专业,包括工程学、纯科学、农业和医学科学等。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

The public prosecutor has decided to release several individuals and will proceed with the prosecution of at least five others.
outrage

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

《Trigger Mortis》于9月8日发行,先于10月26日上映的007新电影《(幽灵党(暂译)》(Spectre)。
Song “Super Shero”(S.H.E.)

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

It is not all bad news for buyers: Prices will still head north next year, but the pace will likely slow from a sprint to a saunter. “Prices can’t just keep going up, up, up on this steep climb,” said Pamela Liebman, the chief executive officer of Corcoran. “Buyers get a little fatigued.”

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

镜头切换到《爱乐之城》的演员和剧组人员那里,他们高兴得抱成一团了,但大家可以听到比蒂好像在说:“应该是爱玛?斯通。”而唐纳薇回应道:“什么?”当《爱乐之城》剧组上台领奖时,可以听到旁边的舞台管理人员说:“哦……哦!天啊!他拿错信封了!”
Yao has been at the center of a hostile takeover battle for China's largest real estate developer China Vanke Co Ltd (000002.SZ).
Meanwhile, exports are expected to continue falling due to the combination of weak global demand and higher prices, as well as China’s decision to effectively re-peg the renminbi to the strengthening dollar.
该学校在这个指标上位列全球第三,排在位于艾哈迈德巴德和班加罗尔的两所印度管理学院之后,这两所学校校友的平均薪资分别为10.9万美元和10.6万美元。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

《美国谍梦》(The Americans):FX频道的这部电视剧以里根时代为背景,它和剧中两位伪装成美国郊区夫妻的克格勃间谍一样具有欺骗性:第二季表面上看是冷战惊悚剧,实际上是关于爱情、家庭、友谊和猜忌的情节剧。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: 家居行业向智能化转型 前景光明
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Britney, YOU drive me crazy for appearing on Loose Women smacking gum like it's 1998 as the panel interrogate you.
曼诺拉·达吉斯
这类开发项目之一,是邓波区(Dumbo)的沃特街(Water Street)60号,一个包含290个单元的出租楼盘,带有24小时门房服务和一个可坐拥曼哈顿景观的屋顶平台。房屋租赁将于下个月开始,两居室的每月房租起价达到了令人瞠目结舌的6018美元(约合人民币3.7万元)。“人们想要体验住在共管公寓的生活,即使他们是租房而不是买房。”花旗居屋负责新开发项目的董事总经理乔迪·安·斯塔斯(Jodi Ann Stasse)说。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Whiteness, in this context, is more than just skin color. You could define it as membership in the “ethno-national majority,” but that’s a mouthful. What it really means is the privilege of not being defined as “other.”
INDOORS: The two-story house, of brick and stucco with a ceramic tile roof, was designed by Dorr & Dorr, completed in 1916 and renovated over the last 15 years. The style is part Prairie, part Arts and Crafts, employing clean lines, open space, elegant woodwork and colored glass. Renovations were done by Joseph Metzler of Sala Architects in Minneapolis.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

该片根据同名童话故事拍摄而成,主要讲述了主人公毛各利的丛林奇遇,他试图在探险中发现自己。他在丛林中遇到很多生物(由众多演员扮演),正是这些生物使他的旅程变得异常艰辛。
10. 2012年搞笑诺贝尔奖之医学奖

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

[pi'tr?uli?m]

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Kim, it's so simple and entry-level Finishing School stuff: keep knees and ankles together and swivel.
"The editors thought the articles were being sent out to genuine reviewers in the discipline," he said. "Following our investigation and communication with the real reviewers, they confirmed they did not conduct the peer review."
Tsinghua University holds the No. 1 spot in both computer science and engineering. The Chinese institution overtook MIT for the top computer science rank this year.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
From the themed collection: 广州“自愿不购买社保”条款无效
Paper

Length-scale dependence of protein hydration-shell density

“现在黑客使用流行文化或体育活动中的常见说法来破解网上账户,因为他们知道很多人在使用这些容易记住的词做密码。”
美联储给当下的新兴市场带来了何种风险?克普克表示,最大的风险之一是,它可能“落在曲线后面”,延误加息太久。相比正确路径,这将导致最终的加息幅度大得出乎意料,最终的利率绝对水平也更高。
It was Somerset Maugham who said the French Riviera is “a sunny place for shady people” – and looking around at all the 'models' in the hotel lobbies and the men in dark sunglasses who seemed to know them, I knew what he meant. Behind the festival's shiny facade, there is an unseemly side – and beneath the azure waters, a polluted mess. The French diver and environmentalist Laurent Lombard's video of the Cannes seabed strewn with waste and debris went viral before the festival began. We were assured there was no danger to swimmers, and the mayor had it cleaned up according to the Daily Mail – but the Med had certainly lost some of its sparkle.
People have been predicting consolidation in this very fragmented sector for years and there have indeed been big mergers recently. But there is little doubt that price pressures on City law firms are intensifying.

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 橱柜定制市场暗藏猫腻
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

詹姆斯也反映出了一种趋势,从邓肯到马努·吉诺比利再到文斯卡特,也都是这样。调理、人体健康科学和营养正在为运动员们铺平道路,保持他们的身体素质,使得他们可以打更多的比赛。或许,在他36岁的时候,詹姆斯仍会是球队中最好的球员,即便现在看来这很疯狂。
urban

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

● “肉桂卷会在人类屁股内爆炸”
Most people’s impression of Sweden is that it’s cold, gloomy and beautiful. But that’s not the whole story. As the largest Scandinavian country with a small population, it’s a paradise for people who hate crowds and love their peace and quiet. It’s the perfect setting in which to enjoy the country’s local delicacies, such as fresh seafood, berries, and regional cheeses.
Company: Eventbrite

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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卡戴珊,这就是女子精修学校入门级的简单礼仪:并拢双膝和脚踝,然后侧身就可以了。
南极洲

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